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T2376

L-甲状腺素

Name: <SC>L</SC>-甲状腺素
Brand: SIGMA

synthetic, ≥98% (HPLC), Metabolism activator, powder

别名:

3,3′,5,5″-四碘代-L-甲状腺原氨酸, 3-[4-(4-羟基-3,5-二碘苯氧基)-3,5-二碘苯基]-L-丙氨酸, T₄

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关于此项目

线性分子式:

HOC₆H₂(I)₂OC₆H₂(I)₂CH₂CH(NH₂)CO₂H

化学文摘社编号:

51-48-9

分子量:

776.87

NACRES:

NA.32

PubChem Substance ID:

24900033

UNSPSC Code:

51111800

EC Number:

200-101-1

MDL number:

MFCD00002595

Beilstein/REAXYS Number:

2228515

eCl@ss:

32190102

Biological source:

synthetic

Form:

powder

Assay:

≥98% (HPLC)

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属性

产品名称

L-甲状腺素, ≥98% (HPLC)

biological source

synthetic

Quality Level

200

sterility

non-sterile

assay

≥98% (HPLC)

form

powder

technique(s)

cell culture | mammalian: suitable

mp

223 °C (dec.) (lit.)

solubility

4 M NH₄OH in methanol: 50 mg/mL, clear to hazy, yellow

shipped in

ambient

storage temp.

room temp

SMILES string

N[C@@H](Cc1cc(I)c(Oc2cc(I)c(O)c(I)c2)c(I)c1)C(O)=O

InChI

1S/C15H11I4NO4/c16-8-4-7(5-9(17)13(8)21)24-14-10(18)1-6(2-11(14)19)3-12(20)15(22)23/h1-2,4-5,12,21H,3,20H2,(H,22,23)/t12-/m0/s1

InChI key

XUIIKFGFIJCVMT-LBPRGKRZSA-N

Gene Information

human ... THRA(7067), THRB(7068), TTR(7276)
mouse ... Cnr2(12802)
rat ... Cnr1(25248)

说明

Application

L-甲状腺素用于研究光诱导的 T4 到 T3 的激素转化在对日本鹌鹑性腺的光周期反应的调节作用。该产品用作测试化合物，用于研究多种激素对培养的大鼠睾丸细胞表面形态的影响。

Biochem/physiol Actions

L甲状腺素 (T₄) 和三碘代-L-甲状腺原氨酸 (T₃) 为含碘激素，由甲状腺卵泡细胞中的甲状腺球蛋白制备。这些激素对代谢率的刺激以及对生长发展的调节似乎归因于它们对 DNA 转录的作用，进而影响蛋白质的合成。

甲状腺素是一种含碘激素，由甲状腺滤泡细胞中的甲状腺球蛋白产生。L-甲状腺素可降低亚临床甲状腺功能减退症患者的总胆固醇水平、低密度脂蛋白胆固醇以及腰臀比。因此，有助于改善心血管危险因素以及能增强疲劳症状。

Packaging

无底玻璃瓶。内含物装在插入的融合锥内。

Preparation Note

L-甲状腺素溶于 4M 甲醇的氢氧化铵溶液中，浓度为 50 mg/ml，得到澄清至浑浊的黄色至暗黄色溶液。

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pictograms

GHS08

signalword

Danger

hcodes

H372

pcodes

P260 - P264 - P270 - P314 - P501

Hazard Classifications

STOT RE 1

target_organs

Thyroid,Cardio-vascular system,Kidney

存储类别

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

法规信息

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历史批次信息供参考:

分析证书(COA)

Lot/Batch Number

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The effects of various hormones on the surface morphology of testicular cells in culture.

J C Hutson

The American journal of anatomy, 151(1), 55-69 (1978-01-01)

The purpose of this investigation was to study the effects of various hormones on the surface morphology of 20-day-old rat testicular cells in culture. Aggregates containing primarily Sertoli cells and germinal cells were obtained by enzymatic digestion. The surface morphology

Light-induced hormone conversion of T4 to T3 regulates photoperiodic response of gonads in birds.

Takashi Yoshimura et al.

Nature, 426(6963), 178-181 (2003-11-14)

Reproduction of many temperate zone birds is under photoperiodic control. The Japanese quail is an excellent model for studying the mechanism of photoperiodic time measurement because of its distinct and marked response to changing photoperiods. Studies on this animal have

The beneficial effect of L-thyroxine on cardiovascular risk factors, endothelial function, and quality of life in subclinical hypothyroidism: randomized, crossover trial.

Salman Razvi et al.

The Journal of clinical endocrinology and metabolism, 92(5), 1715-1723 (2007-02-15)

Subclinical hypothyroidism (SCH) is defined as raised serum TSH levels with circulating thyroid hormones within the reference range. It is uncertain whether treatment of SCH with L-thyroxine improves cardiovascular (CV) risk factors and quality of life. The objective of the

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T2376-100MG	04061837342004
T2376-1G	04061837342028
T2376-500MG	04061837342035
T2376-5G	04061837342066