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T2705

拓扑替康 盐酸盐 水合物

≥98% (HPLC and enzymatic), powder, topoisomerase I inhibitor

别名:

9-[（二甲基氨基）甲基]-10-羟基-（20S）-喜树碱 盐酸盐 水合物, NSC-609669 盐酸盐 水合物, SKF-104864A 盐酸盐 水合物, 拓扑替康 盐酸盐 水合物

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关于此项目

经验公式（希尔记法）:
C23H23N3O5 · xHCl · yH2O
化学文摘社编号:
123948-87-8
分子量:
421.45 (anhydrous free base basis)
UNSPSC Code:
12352200
PubChem Substance ID:
329826724
NACRES:
NA.77
MDL number:
MFCD00870670
Assay:
≥98% (HPLC and enzymatic)
Form:
powder
Quality level:
100
Storage condition:
desiccated, protect from light
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产品名称

拓扑替康 盐酸盐 水合物, ≥98% (HPLC and enzymatic)

Quality Level

100

assay

≥98% (HPLC and enzymatic)

form

powder

storage condition

desiccated, protect from light

color

yellow

solubility

DMSO: ≥20 mg/mL

originator

GlaxoSmithKline

storage temp.

−20°C

SMILES string

[n]21c(cc5c([c]2=O)COC(=O)[C@]5(O)CC)c3nc4c(cc3C1)c(c(cc4)O)CN(C)C

InChI

1S/C23H23N3O5/c1-4-23(30)16-8-18-20-12(9-26(18)21(28)15(16)11-31-22(23)29)7-13-14(10-25(2)3)19(27)6-5-17(13)24-20/h5-8,27,30H,4,9-11H2,1-3H3/t23-/m0/s1

InChI key

UCFGDBYHRUNTLO-QHCPKHFHSA-N

Gene Information

human ... TOP1MT(116447)

Application

拓扑替康作为阳性对照，已被用作低氧条件下人神经胶质瘤细胞中HIF-1α 和VEGF抑制剂的鉴定和分析1。它也被用于 体外 PA317细胞的凋亡检测2。

Biochem/physiol Actions

拓扑替康是一种拓扑异构酶I抑制剂和凋亡诱导剂。它是一种有效的抗肿瘤药。

Features and Benefits

该化合物由GlaxoSmithKline开发。要浏览其他药物开发化合物和批准的药物/候选药物列表，单击此处。
这种化合物是ADME毒性和凋亡研究的特色产品。发现更多有关ADME毒性 和 凋亡 的特色产品。在sigma.com/discover-bsm可了解更多关于生物活性小分子的其他研究领域。

Preparation Note

本品可溶于水，但浓度尚未确定。但多条来源表明，这种化学品在水中的溶解度大于 1 mg/mL。
水合盐酸拓扑替康可溶于DMSO，溶解浓度大于等于20 mg/ml。

pictograms

Health hazard
GHS08

signalword

Danger

Hazard Classifications

Muta. 1B - Repr. 2

存储类别

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

法规信息

涉药品监管产品

此项目有

历史批次信息供参考:

分析证书(COA)

Lot/Batch Number
115M4703V
035M47101V
052M4728V
091M4704V
010M47487

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全球贸易项目编号

货号GTIN
T2705-10MG04061837342905
T2705-50MG04061837342967