T2820
Tazobactam sodium salt
β-lactamase inhibitor
别名:
CL-298741, YTR-830H, [2S-(2α, 3β, 5α)]-3-Methyl-7-oxo-3(1H,2,3-triazol-1-ylmethyl)-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid 4,4-dioxide
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关于此项目
经验公式（希尔记法）:
C10H11N4NaO5S
化学文摘社编号:
分子量:
322.27
NACRES:
NA.85
PubChem Substance ID:
UNSPSC Code:
51282127
MDL number:
Quality Level
form
powder or crystals
color
white to off-white
antibiotic activity spectrum
Gram-negative bacteria, Gram-positive bacteria
mode of action
cell wall synthesis | interferes
SMILES string
[Na+].C[C@]2(Cn1ccnn1)[C@@H](N3[C@@H](CC3=O)S2(=O)=O)C([O-])=O
InChI
1S/C10H12N4O5S.Na/c1-10(5-13-3-2-11-12-13)8(9(16)17)14-6(15)4-7(14)20(10,18)19;/h2-3,7-8H,4-5H2,1H3,(H,16,17);/q;+1/p-1/t7-,8+,10+;/m1./s1
InChI key
RFMIKMMOLPNEDG-QVUDESDKSA-M
General description
Chemical structure: β-lactam
Application
Tazobactam is an antibacterial penicillin derivative which inhibits the action of bacterial β-lactamases. It is used in combination with piperacillin and other β-lactam antibiotics to broaden their spectrum and enhance their effect. It is used for bacterial β-lactamase and penicillinase inhibition studies.
Biochem/physiol Actions
Tazobactam is a β -Lactamase inhibitor. When used with β-lactam antibiotics I, it enhances their effect.
Other Notes
Keep container tightly closed in a dry and well-ventilated place.Keep in a dry place.
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
法规信息
涉药品监管产品
此项目有
R A Bonomo et al.
Biochimica et biophysica acta, 1547(2), 196-205 (2001-06-19)
The CMY-2 beta-lactamase, a plasmid determined class C cephalosporinase, was shown to be susceptible to inhibition by tazobactam (K(i)=40 microM). The reaction product(s) of CMY-2 beta-lactamase with the beta-lactamase inhibitor tazobactam were analyzed by electrospray ionization/mass spectrometry (ESI/MS) to characterize
Gioia S Babini et al.
The Journal of antimicrobial chemotherapy, 51(3), 605-612 (2003-03-05)
MICs of piperacillin/tazobactam are conventionally determined by varying the concentration of piperacillin in the presence of a fixed 4 mg/L tazobactam. When tested in this way, the MIC distribution for Klebsiella isolates with extended-spectrum beta-lactamases (ESBLs) is strongly bimodal, such
In vitro antimicrobial activity of piperacillin/tazobactam in comparison with other broad-spectrum β-lactams. .
Roland, R. K., et al.
The Journal of Infectious Diseases, 4, 226-226 (2000)
全球贸易项目编号
| 货号 | GTIN |
|---|---|
| T2820-10MG | 04061837343346 |