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Merck
CN

T3251

(±)-α-生育酚

synthetic, ≥96% (HPLC)

别名:

DL-全-rac-α-生育酚, 维生素E

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关于此项目

经验公式(希尔记法):
C29H50O2
化学文摘社编号:
分子量:
430.71
NACRES:
NA.77
PubChem Substance ID:
eCl@ss:
34058016
UNSPSC Code:
12352205
EC Number:
233-466-0
MDL number:
Beilstein/REAXYS Number:
94012
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biological source

synthetic

assay

≥96% (HPLC)

form

liquid

technique(s)

HPLC: suitable

color

faint brown to brown, yellow to very dark yellow

solubility

H2O: insoluble, acetone: miscible, chloroform: miscible, ethanol: miscible, vegetable oils: miscible

density

0.950 g/mL at 20 °C (lit.)

storage temp.

2-8°C

SMILES string

CC(C)CCCC(C)CCCC(C)CCCC1(C)CCc2c(C)c(O)c(C)c(C)c2O1

InChI

1S/C29H50O2/c1-20(2)12-9-13-21(3)14-10-15-22(4)16-11-18-29(8)19-17-26-25(7)27(30)23(5)24(6)28(26)31-29/h20-22,30H,9-19H2,1-8H3

InChI key

GVJHHUAWPYXKBD-UHFFFAOYSA-N

Application

(±)-α-生育酚已被用于制备分枝杆菌乳剂。它还用于研究其对流感病毒的免疫调节作用。

Biochem/physiol Actions

δ生育酚(维生素E)由一系列(α、β、γ和δ)手性化合物组成,这些手性化合物的不同之处在于色原烷醇环的酚部分的甲基化程度。它们起到脂溶性抗氧化剂的作用,保护细胞膜免受氧化损伤。α-生育酚被人体吸收发挥有利作用,并且它们的烟酸盐具有维生素E补充剂的作用。研究还报道,维生素E可以预防大鼠中药物诱导型癫痫引起的细胞损伤。

Preparation Note

(±)-α-生育酚可与氯仿、乙醇、乙醚、丙酮和植物油混溶。但是,它实际上不溶于水。 (±)-α-生育酚在碱性条件下不稳定。


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pictograms

Exclamation mark

signalword

Warning

hcodes

Hazard Classifications

Skin Sens. 1

存储类别

10 - Combustible liquids

wgk

WGK 1

ppe

Eyeshields, Gloves



历史批次信息供参考:

分析证书(COA)

Lot/Batch Number

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商品

抗氧化剂可保护生物系统免受含氧自由基和氧化还原过渡金属离子(如铁、铜和镉)引起的氧化损伤。

Antioxidants protect biological systems from oxidative damage produced by oxygen-containing free radicals and from redoxactive transition metal ions such as iron, copper, and cadmium.

DISCOVER Bioactive Small Molecules for Nitric Oxide & Cell Stress Research


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Accumulation and aggregation of misfolded proteins is a hallmark of several diseases collectively known as proteinopathies. Autophagy has a cytoprotective role in diseases associated with protein aggregates. Age-related macular degeneration (AMD) is the most common neurodegenerative eye disease that evokes
M Tagami et al.
Laboratory investigation; a journal of technical methods and pathology, 78(11), 1415-1429 (1998-12-05)
Cerebral ischemia followed by oxygen reperfusion induces apoptosis in hippocampal neurons in stroke-prone spontaneously hypertensive rats (SHRSP) but not in Wistar Kyoto rats (WKY). The overproduction of oxygen-free radicals that occurs in the tissues of SHRSP is implicated in reoxygenation
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Cellular mechanisms involved in multiple neurodegenerative diseases converge on mitochondria to induce overproduction of reactive oxygen species, damage to mitochondria, and subsequent cytochrome c release. Little is currently known regarding the contribution mitochondrial dynamics play in cytochrome c release following



全球贸易项目编号

货号GTIN
T3251-100G04061835549979
T3251-25G04061835522613
T3251-500G04061837343940
T3251-5G04061835514281