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T3258

四环素

98.0-102.0% (HPLC)

别名:

Tetracycline Hydrate

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关于此项目

经验公式（希尔记法）:
C22H24N2O8 · xH2O
化学文摘社编号:
60-54-8
分子量:
444.43 (anhydrous basis)
UNSPSC Code:
51284017
NACRES:
NA.85
PubChem Substance ID:
24900120
EC Number:
200-481-9
Beilstein/REAXYS Number:
2230417
MDL number:
MFCD00151232
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Quality Level

200

assay

98.0-102.0% (HPLC)

form

powder or crystals

storage condition

(Keep container tightly closed in a dry and well-ventilated place. Keep in a dry place.)

color

faint yellow to dark yellow

antibiotic activity spectrum

Gram-negative bacteria, Gram-positive bacteria

mode of action

protein synthesis | interferes

storage temp.

2-8°C

SMILES string

CN(C)[C@H]1[C@@H]2C[C@H]3C(=C(O)[C@]2(O)C(=O)C(C(N)=O)=C1O)C(=O)c4c(O)cccc4[C@@]3(C)O

InChI

1S/C22H24N2O8/c1-21(31)8-5-4-6-11(25)12(8)16(26)13-9(21)7-10-15(24(2)3)17(27)14(20(23)30)19(29)22(10,32)18(13)28/h4-6,9-10,15,25,27-28,31-32H,7H2,1-3H3,(H2,23,30)/t9-,10-,15-,21+,22-/m0/s1

InChI key

OFVLGDICTFRJMM-WESIUVDSSA-N

Gene Information

human ... CYP1A2(1544), TERT(7015)

General description

Chemical structure: tetracycline

Biochem/physiol Actions

作用机制：四环素通过细胞膜中的 proin 通道被动扩散，与 30S 核糖体结合，并通过阻止氨酰基 tRNA 进入 mRNA-核糖体复合物上的受体位点来抑制蛋白质合成。它也与细菌的 50S 核糖体亚基结合，改变膜并导致细胞内成分从细菌细胞中泄漏。通过洗涤可以逆转抑制作用，这表明起到抗菌作用的是可逆结合的抗生素，而不是不可逆结合的药物。

耐药性机制：这种作用通过细胞壁通透性的丧失而失活。

抗菌谱：包括对革兰氏阳性和革兰氏阴性细菌的广泛抗菌活性。

Other Notes

Keep container tightly closed in a dry and well-ventilated place. Keep in a dry place

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Warning

Hazard Classifications

Acute Tox. 4 Oral - Aquatic Chronic 2 - Repr. 2

存储类别

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

dust mask type N95 (US), Eyeshields, Gloves

法规信息

涉药品监管产品

此项目有

历史批次信息供参考:

分析证书(COA)

Lot/Batch Number
068M4127V
107M4040V
067M4187V
037M4121V
047M4100V

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Maulik Thaker et al.
Cellular and molecular life sciences : CMLS, 67(3), 419-431 (2009-10-29)
Resistance to tetracycline emerged soon after its discovery six decades ago. Extensive clinical and non-clinical uses of this class of antibiotic over the years have combined to select for a large number of resistant determinants, collectively termed the tetracycline resistome.
Lucia Pallecchi et al.
Antimicrobial agents and chemotherapy, 51(8), 2720-2725 (2007-06-06)
A survey carried out in 2005 among members of a healthy population of children living in Bolivia and Peru revealed that fecal carriage of Escherichia coli strains resistant to expanded-spectrum cephalosporins was remarkably increased compared to that observed in the
Jennifer M Adams-Haduch et al.
Antimicrobial agents and chemotherapy, 52(11), 3837-3843 (2008-08-30)
A total of 49 unique clinical isolates of multidrug-resistant (MDR) Acinetobacter baumannii identified at a tertiary medical center in Pittsburgh, Pennsylvania, between August 2006 and September 2007 were studied for the genetic basis of their MDR phenotype. Approximately half of
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全球贸易项目编号

货号GTIN
T3258-25G04061837343964
T3258-5G04061837343971
T3258-100G04061833624753