T3830
曲西瑞宾 水合物
≥97% (HPLC)
别名:
API-2, Akt/PKB信号传导抑制剂2, NSC 154020, TCN, VD-0002, 抑制剂 V
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关于此项目
经验公式（希尔记法）:
C13H16N6O4 · xH2O
化学文摘社编号:
分子量:
320.30 (anhydrous basis)
NACRES:
NA.77
PubChem Substance ID:
UNSPSC Code:
12352200
MDL number:
Quality Level
assay
≥97% (HPLC)
form
powder
color
tan
solubility
DMSO: >10 mg/mL
storage temp.
2-8°C
SMILES string
O.Cn1nc(N)c2cn([C@@H]3O[C@H](CO)[C@@H](O)[C@H]3O)c4ncnc1c24
InChI
1S/C13H16N6O4.H2O/c1-18-11-7-5(10(14)17-18)2-19(12(7)16-4-15-11)13-9(22)8(21)6(3-20)23-13;/h2,4,6,8-9,13,20-22H,3H2,1H3,(H2,14,17);1H2/t6-,8-,9-,13-;/m1./s1
InChI key
SPGRLWCWHWRPHX-DOKXERMVSA-N
Gene Information
human ... AKT1(207)
mouse ... AKT1(11651)
rat ... AKT1(24185)
Application
曲西立滨水合物已被用于研究二乙基二硫代氨基甲酸酯（DDC）对肝星状细胞中基质金属蛋白酶-1（MMP-1）的作用1。它还被用于分析过表达瑞典突变APP（SweAPP N2a细胞）的N2a细胞中(-)-表没食子儿茶素-3-没食子酸酯（EGCG）的ADAM 10激活作用2。
Biochem/physiol Actions
曲西瑞宾是一种高度选择性的Akt/PKB抑制剂，可选择性抑制Akt1/2/3的细胞磷酸化/激活。
Preparation Note
曲西立滨水合物溶于DMSO，溶解浓度大于10 mg/ml。
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
Tsubasa Furuhashi et al.
Physiology & behavior, 168, 20-23 (2016-11-05)
Autonomic nervous system (ANS) imbalances are involved in the etiology of cancer, allergy, and collagen diseases. Previously, we hypothesized that FoxO and HSF-1 limit autonomic stress responses via negative feedback on the ANS. Here, we evaluated the role of AKT
Muhammad Miftahussurur et al.
PloS one, 11(12), e0166199-e0166199 (2016-12-03)
Information regarding Helicobacter pylori antibiotic resistance in Indonesia was previously inadequate. We assessed antibiotic susceptibility for H. pylori in Indonesia, and determined the association between virulence genes or genetic mutations and antibiotic resistance. We recruited 849 dyspeptic patients who underwent
Rocío López de la Lama et al.
PloS one, 13(8), e0202971-e0202971 (2018-08-30)
Misconceptions, lack of knowledge, and negative attitudes towards sharks act as barriers preventing actions required to tackle threats to shark populations, limiting the success of global shark conservation initiatives. Peru, a major player for the international trade of shark products
全球贸易项目编号
| 货号 | GTIN |
|---|---|
| T3830-25MG | 04061832452579 |
| T3830-5MG | 04061832452586 |