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T6069

三乙烯硫代磷酰胺

Name: 三乙烯硫代磷酰胺
Brand: SIGMA

别名:

N,N′,N″-三乙撑硫代磷酰胺, 三(1-吖丙啶基)硫代磷酰, 三亚乙基硫代磷酰胺, 三胺硫磷, 噻替哌, 噻替派, 塞替派, 硫次膦基三氮丙啶

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关于此项目

经验公式（希尔记法）:

C₆H₁₂N₃PS

化学文摘社编号:

52-24-4

分子量:

189.22

NACRES:

NA.85

PubChem Substance ID:

24900346

UNSPSC Code:

51102829

EC Number:

200-135-7

MDL number:

MFCD00145452

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属性

form

solid

Quality Level

200

storage condition

(Keep container tightly closed in a dry and well-ventilated place.)

color

white

antibiotic activity spectrum

neoplastics

mode of action

DNA synthesis | interferes

storage temp.

2-8°C

SMILES string

S=P(N1CC1)(N2CC2)N3CC3

InChI

1S/C6H12N3PS/c11-10(7-1-2-7,8-3-4-8)9-5-6-9/h1-6H2

InChI key

FOCVUCIESVLUNU-UHFFFAOYSA-N

说明

General description

化学结构：氮丙啶

Application

多官能烷基化剂

Biochem/physiol Actions

该不稳定的氮碳基团会与 DNA 烷基化，从而导致不可逆的 DNA 损伤。它们通过使 DNA 双螺旋链中的鸟嘌呤核苷交联来阻止肿瘤生长、直接攻击 DNA。DNA 链无法解开和分离，从而阻止了细胞分裂。

Analysis Note

溶解度 - 完全溶于水、氯仿和乙醇（96%）

Other Notes

保存于密闭容器内，置于干燥通风处。

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pictograms

GHS06,GHS08

signalword

Danger

hcodes

H300,H350

pcodes

P202 - P264 - P280 - P301 + P310 - P405 - P501

Hazard Classifications

Acute Tox. 2 Oral - Carc. 1B

存储类别

6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials

wgk

WGK 3

ppe

Eyeshields, Faceshields, Gloves, type P3 (EN 143) respirator cartridges

历史批次信息供参考:

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Lot/Batch Number

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A Fabi et al.

Annals of oncology : official journal of the European Society for Medical Oncology, 6(2), 187-189 (1995-02-01)

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全球贸易项目编号

货号	GTIN
T6069-1G	04061826759158