T7165
酪磷蛋白23
≥98%
别名:
RG-50810, （3,4-二羟基亚苄基）丙二腈
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关于此项目
经验公式（希尔记法）:
C10H6N2O2
化学文摘社编号:
分子量:
186.17
NACRES:
NA.77
PubChem Substance ID:
UNSPSC Code:
12352200
MDL number:
biological source
synthetic (organic)
Quality Level
assay
≥98%
form
powder
potency
35 μM IC50
solubility
DMSO: soluble 50 mg/mL, clear, yellow to brownish-yellow
storage temp.
2-8°C
SMILES string
Oc1ccc(cc1O)\C=C(\C#N)C#N
InChI
1S/C10H6N2O2/c11-5-8(6-12)3-7-1-2-9(13)10(14)4-7/h1-4,13-14H
InChI key
VTJXFTPMFYAJJU-UHFFFAOYSA-N
Gene Information
human ... CDK2(1017)
Application
Tyrphostin 23可作为酪氨酸激酶抑制剂用于研究大鼠ghrelin诱导的GH3细胞MAPK激活。Tyrphostin 23也被用作分析其对神经磷酸酶（SN）诱导的中性粒细胞趋化的作用。
Biochem/physiol Actions
Tyrphostin 23是表皮生长因子（EGF）受体激酶功能的小分子抑制剂。该分子与蛋白酪氨酸激酶（PTK）结构域的底物亚位点结合。
Features and Benefits
这种化合物是激酶磷酸酶生物学研究的特色产品。点击此处发现更多特色激酶磷酸酶生物产品。在sigma.com/discover-bsm可了解更多关于生物活性小分子的其他研究领域。
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
商品
Discover Bioactive Small Molecules for Kinase Phosphatase Biology
Zhiying Zhao et al.
Pflugers Archiv : European journal of physiology, 456(2), 413-423 (2007-12-19)
Inwardly rectifying potassium channels play an important role in the maintenance of membrane potential in neurons and myocardium. Identification of functional regulation mechanisms concerning these channels may lead to the development of specific modulators for these channels. Genistein is an
Sheung Kwan Lam et al.
The Plant journal : for cell and molecular biology, 60(5), 865-881 (2009-08-28)
Brefeldin A (BFA) is a useful tool for studying protein trafficking and identifying organelles in the plant secretory and endocytic pathways. At low concentrations (5-10 microg ml(-1)), BFA caused both the Golgi apparatus and trans-Golgi network (TGN), an early endosome
Nathalie Leborgne-Castel et al.
Plant physiology, 146(3), 1255-1266 (2008-01-11)
The plant defense elicitor cryptogein triggers well-known biochemical events of early signal transduction at the plasma membrane of tobacco (Nicotiana tabacum) cells, but microscopic observations of cell responses related to these early events were lacking. We determined that internalization of
全球贸易项目编号
| 货号 | GTIN |
|---|---|
| T7165-5MG | 04061837372339 |
| T7165-25MG | 04061832452708 |