T7329
滔罗林
>97% (NMR), powder
别名:
4,4′-亚甲双[四氢-2H-1,2,4-噻二嗪]1,1,1′,1′-四氧化物, 4,4′-亚甲基双(四氢-1,2,4-磺胺嘧啶 1,1-二氧化物), 牛磺罗定
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关于此项目
经验公式（希尔记法）:
C7H16N4O4S2
化学文摘社编号:
分子量:
284.36
NACRES:
NA.77
PubChem Substance ID:
UNSPSC Code:
12352200
EC Number:
243-016-5
MDL number:
Quality Level
assay
>97% (NMR)
form
powder
storage condition
protect from light
color
white to off-white
solubility
DMSO: >20 mg/mL
storage temp.
room temp
SMILES string
O=S1(=O)CCN(CN1)CN2CCS(=O)(=O)NC2
InChI
1S/C7H16N4O4S2/c12-16(13)3-1-10(5-8-16)7-11-2-4-17(14,15)9-6-11/h8-9H,1-7H2
InChI key
AJKIRUJIDFJUKJ-UHFFFAOYSA-N
Biochem/physiol Actions
滔罗林是一种具有抗肿瘤活性的广谱抗生素，可以引起细胞凋亡并减少肿瘤细胞增殖。
滔罗林是一种具有抗肿瘤活性的广谱抗生素，可以引起细胞凋亡并减少肿瘤细胞增殖。滔罗林已与肿瘤坏死因子相关凋亡诱导配体 (TRAIL) 搭配使用以描述许多细胞凋亡相关信号蛋白的协同反应。由于无毒的滔罗林可以降低重组人肿瘤坏死因子相关凋亡诱导配体 (rhTRAIL) 的毒性和剂量，因此滔罗林与 rhTRAIL 联用的治疗方式可以为癌症治疗提供新的选择。滔罗林也被用作研究细胞凋亡和坏死的多种机理的工具。
Taurolidine is an antibacterial agent that can be used for the treatment of peritonis. It has also been used as an antiendoxic substance for systematic inflammatory response syndrome and as an anti-angiogenic agent for tumors. Furthermore, studies have reported that taurolidine can be used for the prevention of multiple catheter-related bloodstream infections.
Preparation Note
Taurolidine is soluble in DMSO at a concentration that is greater than 20 mg/ml.
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
法规信息
新产品
此项目有
Mette Møller Handrup et al.
APMIS : acta pathologica, microbiologica, et immunologica Scandinavica, 120(10), 794-801 (2012-09-11)
Taurolidine has demonstrated inhibition of biofilm formation in vitro. The aim of this study was to compare the effect of catheter locking with taurolidine vs heparin in biofilm formation in central venous catheters. Forty-eight children with cancer were randomized to
Kevin Marley et al.
BMC veterinary research, 9, 15-15 (2013-01-22)
Osteosarcoma (OS) affects over 8000 dogs/year in the United States. The disease usually arises in the appendicular skeleton and metastasizes to the lung. Dogs with localized appendicular disease benefit from limb amputation and chemotherapy but most die within 6-12 months
Vassilis Filiopoulos et al.
American journal of nephrology, 33(3), 260-268 (2011-03-05)
Use of uncuffed catheters (UCs) in hemodialysis patients is common practice. An antibiotic lock has been recommended to prevent catheter-related bacteremia (CRB), although insufficient data are available about the appropriate antimicrobial agent and dose with prolonged use of UCs. This
全球贸易项目编号
| 货号 | GTIN |
|---|---|
| T7329-25MG | 04061832926926 |
| T7329-5MG | 04061837372674 |