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关于此项目
Technique(s):
immunohistochemistry: suitable, immunocytochemistry: suitable, immunoprecipitation (IP): suitable, western blot: 0.25-0.5 μg/mL using PC12 cell extract
Conjugate:
unconjugated
Application:
ICC, IHC, IP, WB
Citations:
145
产品名称
抗-β微管蛋白III (神经元)抗体,小鼠单克隆 小鼠抗, ~1.0 mg/mL, clone 2G10, purified from hybridoma cell culture
biological source
mouse
Quality Level
conjugate
unconjugated
antibody form
purified from hybridoma cell culture
antibody product type
primary antibodies
clone
2G10, monoclonal
form
buffered aqueous solution
mol wt
antigen ~50 kDa
species reactivity
human, mouse, rat
packaging
antibody small pack of 25 μL
concentration
~1.0 mg/mL
technique(s)
immunohistochemistry: suitable, immunocytochemistry: suitable, immunoprecipitation (IP): suitable, western blot: 0.25-0.5 μg/mL using PC12 cell extract
isotype
IgG2a
UniProt accession no.
shipped in
dry ice
storage temp.
−20°C
target post-translational modification
unmodified
Gene Information
human ... TUBB3(10381)
mouse ... Tubb3(22152)
rat ... Tubb3(246118)
General description
微管蛋白 β 3 III类(TUBB3)也称 β-微管蛋白III,由定位于人染色体16q24.3的基因编码。TUBB3蛋白表达仅限于神经元。
Application
小鼠抗β-微管蛋白III(神经元)单克隆抗体还可用于以下研究:
- 免疫荧光。
- 免疫细胞化学。
Biochem/physiol Actions
微管蛋白 β 3 III类(TUBB3)在神经系统发育和轴突导向中起着至关重要的作用。编码蛋白的基因发生突变会导致眼动障碍、3型先天性眼外肌纤维化(CFEOM3)和各种神经综合征。蛋白表达的改变会影响微管动力学和微管-驱动蛋白相互作用。在肿瘤组织中,TUBB3的表达上调。TUBB3的表达下调可以作为皮肤恶性黑素瘤预后不良的重要标志物。TUBB3参与抑制肿瘤组织的侵袭性生长;因此,它是开发抗肿瘤药物的潜在靶标。
Physical form
0.01M 磷酸缓冲盐溶液,pH 7.4,含 15mM 叠氮化钠。
Other Notes
Disclaimer
除非我们的产品目录或产品随附的其他公司文档中另有说明,否则我们的产品仅供研究使用,不得用于任何其他目的,包括但不限于未经授权的商业用途、体外诊断用途、离体或体内治疗用途或任何类型的消费或应用于人或动物。
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存储类别
10 - Combustible liquids
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)
法规信息
常规特殊物品
低风险生物材料
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全球贸易项目编号
| 货号 | GTIN |
|---|---|
| T8578-200UL | 04061837379383 |
| T8578-100UL | 04061837379376 |