T8700
抗-酪氨酸羟化酶 兔抗
affinity isolated antibody, buffered aqueous glycerol solution, sufficient for 10 blots
别名:
Rabbit Anti-TYH
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关于此项目
Conjugate:
unconjugated
Clone:
polyclonal
Application:
IF, IHC (f), WB
Citations:
60
biological source
rabbit
Quality Level
conjugate
unconjugated
antibody form
affinity isolated antibody
antibody product type
primary antibodies
clone
polyclonal
form
buffered aqueous glycerol solution
usage
sufficient for 10 blots
species reactivity
mammals
technique(s)
immunohistochemistry (frozen sections): 1:1,000, indirect immunofluorescence: 1:1,000, western blot: 1:1,000 using rat brain lysates of PC-12 cells stimulated by okadaic acid
shipped in
wet ice
storage temp.
−20°C
target post-translational modification
unmodified
General description
酪氨酸羟化酶 (TH) 由定位于人染色体 11p15 的基因编码。TH 是四种相同亚基组成的四聚体，特征是含有一个调节、催化和四聚体化结构域。该酶利用酪氨酸、四氢生物蝶呤 (BH4) 和 O2 作为辅底物，并利用 Fe2+ 作为辅因子。
酪氨酸羟化酶（TH）可参与到苯丙氨酸向多巴胺的转化。它可催化儿茶酚胺生物合成途径的初始限速步骤。
Immunogen
从嗜铬细胞瘤中纯化并经SDS变性的大鼠酪氨酸羟化酶。
Biochem/physiol Actions
酪氨酸羟化酶 (TH) 催化儿茶酚胺神经递质生物合成的第一个限速步骤，即 L-酪氨酸转化为 L-多巴的过程。L-苯丙氨酸对 TH 的抑制作用可能在苯丙酮尿症中发挥关键作用，并可阻止去甲肾上腺素合成。TH 活性可通过磷酸化来调节。TH 表达下调与各种神经精神疾病有关，例如精神分裂症和帕金森病 (PD)。
Physical form
含有10mM HEPES，pH 7.5、150mM NaCl、100 μg/mL BSA和50%甘油的100 μL溶液。
Other Notes
Disclaimer
除非我们的产品目录或产品附带的其他公司文档另有说明，否则我们的产品仅供研究使用，不得用于任何其他目的，包括但不限于未经授权的商业用途、体外诊断用途、离体或体内治疗用途或任何类型的消费或应用于人类或动物。
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存储类别
10 - Combustible liquids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)
法规信息
常规特殊物品
低风险生物材料
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全球贸易项目编号
| 货号 | GTIN |
|---|---|
| T8700-1VL | 04061837379604 |