T9025
硫利达嗪 盐酸盐
≥99%, D2 dopamine receptor antagonist
别名:
10-[2-（1-甲基-2-哌啶基）乙基]-2-（甲硫基）-10H-吩噻嗪 盐酸盐
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经验公式（希尔记法）:
C21H26N2S2 · HCl
化学文摘社编号:
分子量:
407.04
NACRES:
NA.77
PubChem Substance ID:
UNSPSC Code:
12352200
EC Number:
204-992-8
MDL number:
Assay:
≥99%
Quality level:
产品名称
硫利达嗪 盐酸盐, ≥99%
Quality Level
assay
≥99%
solubility
H2O: soluble 250 mg plus 5 ml of solvent, clear, colorless to faintly yellow, chloroform: soluble, diethyl ether: insoluble, ethanol: soluble, methanol: soluble
SMILES string
Cl.CSc1ccc2Sc3ccccc3N(CCC4CCCCN4C)c2c1
InChI
1S/C21H26N2S2.ClH/c1-22-13-6-5-7-16(22)12-14-23-18-8-3-4-9-20(18)25-21-11-10-17(24-2)15-19(21)23;/h3-4,8-11,15-16H,5-7,12-14H2,1-2H3;1H
InChI key
NZFNXWQNBYZDAQ-UHFFFAOYSA-N
Gene Information
human ... DRD2(1813), DRD3(1814), DRD4(1815), HTR2A(3356), HTR2C(3358)
Application
盐酸噻哒嗪已被用作嵌入剂，使用方波伏安法（SWV）技术分析双链DNA（dsDNA）的完整性。盐酸噻哒嗪还被用作抑制人肝微粒体中肝酶细胞色素P4502D6（CYP2D6）的阳性对照。
Biochem/physiol Actions
D2 多巴胺受体拮抗剂； 吩噻嗪类抗精神病药，减少锥体束外副作用； Ca2+ 通道阻滞剂。
Preparation Note
250 mg盐酸硫代哒嗪可溶于5 ml水中，生成透明、无色至微黄色溶液。盐酸噻哒嗪也可溶于甲醇、乙醇和氯仿，但不溶于乙醚。
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signalword
Warning
hcodes
Hazard Classifications
Acute Tox. 4 Oral
存储类别
11 - Combustible Solids
wgk
WGK 3
ppe
dust mask type N95 (US), Eyeshields, Gloves
Michael Stenger et al.
PloS one, 10(8), e0135571-e0135571 (2015-08-13)
The rise in antimicrobial resistance is a major global concern and requires new treatment strategies. The use of helper compounds, such as thioridazine (TDZ), an antipsychotic drug, in combination with traditional antibiotics must be investigated. The aim of this study
H K Crewe et al.
British journal of clinical pharmacology, 34(3), 262-265 (1992-09-01)
Inhibition of human cytochrome P4502D6 (CYP2D6)-catalysed metabolism can lead to clinically significant alterations in pharmacokinetics. Since there is evidence that the selective serotonin reuptake inhibitor (SSRI) class of antidepressant drugs might inhibit CYP2D6, the effects of five SSRIs on human
J S Someren et al.
Biochemical and biophysical research communications, 260(3), 619-625 (1999-07-15)
We have shown that heat shock proteins (HSPs) associated with steroid receptor complexes are involved in the activation of calcineurin by aldosterone and dexamethasone. To determine whether HSPs directly interact with calcineurin, we measured the effect of HSPs 90, 70
全球贸易项目编号
| 货号 | GTIN |
|---|---|
| T9025-25G | 04061837380235 |
| T9025-5G | 04061837380242 |