T9283
Anti-Tropomyosin (Sarcomeric) antibody, Mouse monoclonal
clone CH1, purified from hybridoma cell culture
别名:
Monoclonal Anti-Tropomyosin (Sarcomeric) antibody produced in mouse, Anti-C15orf13, Anti-CMD1Y, Anti-CMH3, Anti-HEL-S-265, Anti-HTM-alpha, Anti-LVNC9, Anti-TMSA
登录 查看组织和合同定价。
选择尺寸
变更视图
关于此项目
Conjugate:
unconjugated
Clone:
CH1, monoclonal
Application:
ARR, IHC (f), IHC (p), IP, WB
Citations:
49
biological source
mouse
Quality Level
conjugate
unconjugated
antibody form
purified from hybridoma cell culture
antibody product type
primary antibodies
clone
CH1, monoclonal
contains
15 mM sodium azide
species reactivity
human, chicken, rat
technique(s)
immunohistochemistry (formalin-fixed, paraffin-embedded sections): 1:50 using sections of human tongue, immunohistochemistry (frozen sections): suitable using human and animal tissue sections, immunoprecipitation (IP): suitable, microarray: suitable, western blot: suitable using native preparations
isotype
IgG1
UniProt accession no.
shipped in
dry ice
storage temp.
−20°C
target post-translational modification
unmodified
Gene Information
chicken ... TPM1(396366)
human ... TPM1(7168)
rat ... Tpm1(24851)
General description
Tropomyosin 1 (TPM1) is encoded by the gene mapped to human chromosome 15q22.2. The encoded protein belongs to the TPM protein family.
Immunogen
chicken muscle tropomyosin.
Application
Applications in which this antibody has been used successfully, and the associated peer-reviewed papers, are given below.
Immunohistochemistry (1 paper)
Immunohistochemistry (1 paper)
Monoclonal Anti-Tropomyosin (sarcomeric) antibody produced in mouse has been used in immunofluorescence and immunohistochemistry.
Biochem/physiol Actions
The antibody recognizes an epitope on skeletal and cardiac tropomyosin. The antibody shows no reaction with denatured protein by immunoblotting. No cross-reactivity has been observed with smooth muscle or non-muscle tropomyosin.
Tropomyosin 1 (TPM1) is a potent tumor suppressor gene. It is expressed at low levels in various types of solid cancers including, oral squamous cell carcinoma (OSCC) and tongue squamous cell carcinoma. Mutation in the gene is associated with the development of hypertrophic cardiomyopathy. The encoded protein is involved in the regulation of actin-myosin interaction in striated muscles. Tropomyosin plays an essential role in Ca2+ -regulated contraction of cardiac muscle.
Physical form
Physical form: Solution in 0.01 M phosphate buffered saline, pH 7.4, containing 15 mM sodium azide.
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Still not finding the right product?
试用我们的 产品选型工具 工具缩小选择范围
存储类别
12 - Non Combustible Liquids
wgk
nwg
flash_point_f
Not applicable
flash_point_c
Not applicable
法规信息
动物来源生物产品
常规特殊物品
常规特殊物品
此项目有
相关内容
K H Grinnemo et al.
The Journal of thoracic and cardiovascular surgery, 127(5), 1293-1300 (2004-04-30)
It is thought that adult human mesenchymal stem cells do not induce immunoreactivity even to xenografts. We wanted to study whether adult human mesenchymal stem cells survive and engraft in experimentally induced ischemic rat myocardium. Bone marrow-derived adult human mesenchymal
Natalie Gude et al.
Circulation research, 99(4), 381-388 (2006-07-15)
Activation of Akt is associated with enhanced cell cycling and cellular proliferation in nonmyocytes, but this effect of nuclear Akt accumulation has not been explored in the context of the myocardium. Cardiac-specific expression of nuclear-targeted Akt (Akt/nuc) in transgenics prolongs
Tropomyosin-1 acts as a potential tumor suppressor in human oral squamous cell carcinoma
Pan H
PLoS ONE, 12, e0168900-e0168900 (2017)
全球贸易项目编号
| 货号 | GTIN |
|---|---|
| T9283-.2ML | 04061837381232 |