主要文件

查看所有文档

U104

UK 14,304

Name: UK 14,304
Brand: SIGMA

别名:

5-Bromo-N-(2-imidazolin-2-yl)-6-quinoxalinamine, 5-Bromo-N-(4,5-dihydro-1H-imidazol-2-yl)-6-quinoxalinamine, Brimonidine

登录查看组织和合同定价。

选择尺寸

变更视图

关于此项目

经验公式（希尔记法）:

C₁₁H₁₀BrN₅

化学文摘社编号:

59803-98-4

分子量:

292.13

NACRES:

NA.77

PubChem Substance ID:

24277812

UNSPSC Code:

12352200

MDL number:

MFCD00153878

Quality level:

100

技术服务

需要帮助？我们经验丰富的科学家团队随时乐意为您服务。

让我们为您提供帮助

属性

Quality Level

100

solubility

45% (w/v) aq 2-hydroxypropyl-β-cyclodextrin: <0.8 mg/mL, DMSO: >6.5 mg/mL, ethanol: <8 mg/mL (warm), H₂O: insoluble

SMILES string

Brc1c(NC2=NCCN2)ccc3nccnc13

InChI

1S/C11H10BrN5/c12-9-7(17-11-15-5-6-16-11)1-2-8-10(9)14-4-3-13-8/h1-4H,5-6H2,(H2,15,16,17)

InChI key

XYLJNLCSTIOKRM-UHFFFAOYSA-N

Gene Information

human ... ADRA1A(148), ADRA2A(150), ADRA2B(151), ADRA2C(152)

说明

Application

在心外膜冠状动脉培养中，UK 14,304 已用于激活细胞外信号调节激酶 (ERK)

UK 14,304 已用于肠肌间神经元，以研究 R 型钙电流的抑制。UK 14,304 也曾用于免疫荧光显微术分析。

Biochem/physiol Actions

UK 14,304 是 α2-肾上腺素受体激动剂。UK 14,304 抑制激素敏感型脂肪酶 (HSL) 活性并抑制脂肪组织中的脂肪生成。

Features and Benefits

该化合物在受体分类和信号转导手册中α2-肾上腺素能受体页面中进行了详细介绍。想要浏览手册的其他页面，请单击此处。

Preparation Note

UK 14,304 可溶于 45%（w/v）aq 2-羟丙基-β--环糊精（<0.8 mg/mL), DMSO (> 6.5 mg/mL）和乙醇（<8 mg/mL）。但它不溶于水。

pictograms

GHS06

signalword

Danger

hcodes

H301

pcodes

P264 - P270 - P301 + P310 - P405 - P501

Hazard Classifications

Acute Tox. 3 Oral

存储类别

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

wgk

WGK 1

flash_point_f

Not applicable

flash_point_c

Not applicable

历史批次信息供参考:

分析证书(COA)

Lot/Batch Number

没有发现合适的版本？

如果您需要特殊版本，可通过批号或批次号查找具体证书。

搜索COA

已有该产品？

在文件库中查找您最近购买产品的文档。

访问文档库

商品

α2-Adrenoceptors

Learn about alpha-2 adrenoceptor and its subtypes, mediated responses, and applications of agonists. Included is a list of available products and a comparison table.

Investigating the neuroprotective effect of Copolymer-1 in acute primary angle closure - Interim report of a randomized placebo-controlled double-masked clinical trial.

Kenric Rui-Pin Fan et al.

Acta ophthalmologica, 97(6), e827-e832 (2019-03-28)

To investigate the neuroprotective effect of Copolymer-1 (Cop-1) in patients with acute primary angle closure (APAC) in a randomized double-masked controlled trial. After initial medical management, APAC patients were randomized to receive either subcutaneous Cop-1 or placebo within 24 hr and

Effects of acute and chronic ethanol administration on the response of mouse adipose tissue hormone-sensitive lipase to alpha2-adrenoceptor activation by UK 14304.

Shih MF and Taberner PV

Alcohol and Alcoholism (Oxford, Oxfordshire), 36(5), 381-387 (2001)

Alpha2 -adrenoceptor agonists inhibit form-deprivation myopia in the chick.

Brittany J Carr et al.

Clinical & experimental optometry, 102(4), 418-425 (2019-01-31)

The putative myopia-controlling receptor is thought to be muscarinic acetylcholine receptor subtype M4 , because mamba toxin-3 can inhibit form-deprivation myopia in chicks at a far lower concentration than atropine. However, mamba toxin-3 is equally potent at the human α1A

查看所有相关文献

全球贸易项目编号

货号	GTIN
U104-100MG	04061832094168
U104-25MG	04061837403910
U104-5MG	04061837404047