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Merck
CN

U5127

熊去氧胆酸

≥99%

别名:

3α,7β-二羟基-5β-胆酸-24-羧酸, 5β-胆酸-24-羧酸-3α,7β-二醇, 7β-羟基石胆酸, UDCS

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关于此项目

经验公式(希尔记法):
C24H40O4
化学文摘社编号:
分子量:
392.57
UNSPSC Code:
12161900
NACRES:
NA.25
PubChem Substance ID:
EC Number:
204-879-3
Beilstein/REAXYS Number:
3219888
MDL number:
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description

anionic detergent

Quality Level

assay

≥99%

form

powder

mol wt

392.57 g/mol

mp

203-204 °C (lit.)

SMILES string

C[C@H](CCC(O)=O)[C@H]1CC[C@H]2[C@@H]3[C@@H](O)C[C@@H]4C[C@H](O)CC[C@]4(C)[C@H]3CC[C@]12C

InChI

1S/C24H40O4/c1-14(4-7-21(27)28)17-5-6-18-22-19(9-11-24(17,18)3)23(2)10-8-16(25)12-15(23)13-20(22)26/h14-20,22,25-26H,4-13H2,1-3H3,(H,27,28)/t14-,15+,16-,17-,18+,19+,20+,22+,23+,24-/m1/s1

InChI key

RUDATBOHQWOJDD-UZVSRGJWSA-N

Gene Information

human ... NR1H4(9971)

Application

熊去氧胆酸(UDCS)是一种细胞保护剂,广泛用于缓解肝脏和胆道疾病。 熊去氧胆酸可用于研究其特定活性,包括减少胆固醇吸收,溶解胆固醇胆结石,以及抑制免疫反应。


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存储类别

11 - Combustible Solids

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)



历史批次信息供参考:

分析证书(COA)

Lot/Batch Number

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实验方案

Investigate bile acid roles in gut hormone profiles and glycemic control, vital for clinical labs exploring potential mechanisms.

相关内容

Bile Acids (BA) are synthesized in the liver and play important roles in cholesterol homeostasis, absorption of vitamins and lipids, and various key metabolic processes.


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Journal of biomolecular screening, 15(5), 488-497 (2010-05-08)
Dietary long-chain fatty acid (LCFA) uptake across cell membranes is mediated principally by fatty acid transport proteins (FATPs). Six subtypes of this transporter are differentially expressed throughout the human and rodent body. To facilitate drugs discovery against FATP subtypes, the
Ruchika Sharma et al.
Journal of medicinal chemistry, 54(1), 122-130 (2010-12-17)
Ursodeoxycholic acid (UDCA) is used for the treatment of hepatic inflammatory diseases. Recent studies have shown that UDCA's biological effects are partly glucocorticoid receptor (GR) mediated. UDCA derivatives were synthesized and screened for ability to induce GR translocation in a
Peter Fickert et al.
Hepatology (Baltimore, Md.), 58(6), 2056-2069 (2013-07-03)
Tubular epithelial injury represents an underestimated but important cause of renal dysfunction in patients with cholestasis and advanced liver disease, but the underlying mechanisms are unclear. To address the hypothesis that accumulation and excessive alternative urinary elimination of potentially toxic



全球贸易项目编号

货号GTIN
U5127-25G04061837409714
U5127-1G04061837409707
U5127-5G04061837409721