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U6881

U-73343

Name: U-73343
Brand: SIGMA

别名:

1-[6-[((17β)-3-Methoxyestra-1,3,5[10]-trien-17-yl)amino]hexyl]-2,5-pyrrolidinedione

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关于此项目

经验公式（希尔记法）:

C₂₉H₄₂N₂O₃

化学文摘社编号:

142878-12-4

分子量:

466.66

NACRES:

NA.77

PubChem Substance ID:

24900662

UNSPSC Code:

41106300

MDL number:

MFCD00211221

Assay:

≥98% (HPLC)

Form:

powder

Quality level:

200

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属性

assay

≥98% (HPLC)

Quality Level

200

form

powder

color

white

solubility

DMSO: soluble

SMILES string

[H][C@]12CC[C@]3(C)[C@H](CC[C@@]3([H])[C@]1([H])CCc4cc(OC)ccc24)NCCCCCCN5C(=O)CCC5=O

InChI

1S/C29H42N2O3/c1-29-16-15-23-22-10-8-21(34-2)19-20(22)7-9-24(23)25(29)11-12-26(29)30-17-5-3-4-6-18-31-27(32)13-14-28(31)33/h8,10,19,23-26,30H,3-7,9,11-18H2,1-2H3/t23-,24-,25+,26+,29+/m1/s1

InChI key

CJHWFIUASFBCKN-ZRJUGLEFSA-N

说明

General description

U-73343 is used to assess the involvement of G protein-coupled 1-phosphatidylinositol-phosphodiesterase or phospholipase C in receptor-mediated cell activation. It functions downstream of phospholipase C to block receptor-mediated phospholipase D activation.

Application

U-73343 has been used in measuring the fluorescence of intracellular Ca²⁺.

U-73343 has been used for studying the role of phospholipase C (PLC) signaling in modulating epithelial Na⁺ channel (ENaC) function in gerbil Reissner′s membranes (RMs). U-73343 has also been used as a negative control for PLC inhibition in mechanically stimulated (MS) and its neighboring (NB) cells.

Biochem/physiol Actions

Inactive analog of U73122; used as a negative control.

Preparation Note

U-73343 is soluble in chloroform at 10 mg/ml and yields a clear, colorless to faint yellow solution. It is also soluble in ethanol (0.93 mg/ml) and DMSO (2.3 mg/ml), but is insoluble in water.

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存储类别

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

dust mask type N95 (US), Eyeshields, Gloves

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Group I metabotropic glutamate receptors reduce excitotoxic injury and may facilitate neurogenesis.

Andrius Baskys et al.

Neuropharmacology, 49 Suppl 1, 146-156 (2005-07-19)

Group I metabotropic glutamate receptor (mGluR) agonist DHPG reduced nerve cell death caused by their exposure to NMDA ("neuroprotective effect") and attenuated NMDA receptor-mediated currents [Blaabjerg, M., Baskys, A., Zimmer, J., Vawter, M. P., 2003b. Changes in hippocampal gene expression

ATP-dependent paracrine intercellular communication in cultured bovine corneal endothelial cells.

Priya Gomes et al.

Investigative ophthalmology & visual science, 46(1), 104-113 (2004-12-30)

Intercellular communication (IC) in nonexcitable cells is mediated through gap junctions and/or through the release of paracrine mediators. This study was conducted to investigate adenosine-5' triphosphate (ATP)-dependent paracrine IC in the propagation of Ca2+ waves in confluent monolayers of cultured

Inhibitory effects of U73122 and U73343 on Ca2+ influx and pore formation induced by the activation of P2X7 nucleotide receptors in mouse microglial cell line.

Takato Takenouchi et al.

Biochimica et biophysica acta, 1726(2), 177-186 (2005-08-27)

P2X7 receptors are ATP-gated ion channels and play important roles in microglial functions in the brain. Activation of P2X7 receptors by ATP or its agonist BzATP induces Ca2+ influx from extracellular space, followed by the formation of non-selective membrane pores

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全球贸易项目编号

货号	GTIN
U6881-1MG	04061837410031
U6881-5MG	04061837410048