V1255
D -缬氨酸
BioReagent, suitable for cell culture
别名:
D-α-氨基异戊酸, D-2-氨基-3-甲基丁酸
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关于此项目
线性分子式:
(CH3)2CHCH(NH2)CO2H
化学文摘社编号:
分子量:
117.15
UNSPSC Code:
12352209
NACRES:
NA.75
PubChem Substance ID:
EC Number:
211-368-9
Beilstein/REAXYS Number:
1721135
MDL number:
biological source
synthetic (organic)
Quality Level
product line
BioReagent
form
powder
technique(s)
cell culture | mammalian: suitable
mp
>295 °C (subl.) (lit.)
shipped in
ambient
storage temp.
room temp
SMILES string
CC(C)[C@@H](N)C(O)=O
InChI
1S/C5H11NO2/c1-3(2)4(6)5(7)8/h3-4H,6H2,1-2H3,(H,7,8)/t4-/m1/s1
InChI key
KZSNJWFQEVHDMF-SCSAIBSYSA-N
General description
L-缬氨酸是一种必需的非极性氨基酸。D-缬氨酸是缬氨酸的非蛋白异构体。
Application
D-缬氨酸已用作下列培养基的补充剂：
- 杜氏改良Eagle培养基(DMEM)/营养混合物F-12 Ham (F-12)，用于小鼠肾近曲小管上皮细胞(RPTC)培养
- 内皮细胞生长培养基MV2，用于大鼠肺微血管内皮细胞(RLMEC)培养
- DMEM/F-12培养基，用于小鼠气管上皮细胞(MTEC)培养
Biochem/physiol Actions
D-缬氨酸适于半合成兽用抗生素、药物和农药等广泛生产应用。
D-缬氨酸在细胞培养中可用作细胞增殖的选择性抑制剂，主要抑制D-氨基酸氧化酶缺乏细胞。 D-缬氨酸一直以来均被用于抑制成纤维细胞生长，同时允许上皮细胞选择性生长。
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存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
V A Lazzaro et al.
Research communications in chemical pathology and pharmacology, 75(1), 39-48 (1992-01-01)
A selective cell culture medium, D-valine minimal essential medium (92 mg/l), has been developed to inhibit the proliferation of fibroblasts in cell culture (Gilbert & Migeon 1975). Substitution of D-valine for L-valine prevents fibroblast growth due to the absence of
Ming Chen et al.
World journal of microbiology & biotechnology, 32(10), 171-171 (2016-08-28)
D-Valine is an important organic chiral source and has extensive industrial application, which is used as intermediate for the synthesis of agricultural pesticides, semi-synthetic veterinary antibiotics and pharmaceutical drugs. Its derivatives have shown great activity in clinical use, such as
Phillip C Calder
The Journal of nutrition, 136(1 Suppl), 288S-293S (2005-12-21)
Although there has been great interest in the effects of amino acids on immune function, little is known about the impact of changes in BCAA availability on the ability of the immune system to function. Human immune cells incorporate BCAA
全球贸易项目编号
| 货号 | GTIN |
|---|---|
| V1255-1G | 04061837429156 |
| V1255-25G | 04061837429163 |
| V1255-5G | 04061837429170 |