WH0003845M1
Anti-KRAS Antibody
mouse monoclonal, 3B10-2F2
别名:
抗CKRAS, 抗KIRAS, 抗KRAS1, 抗KRAS2, 抗KRAS2A, 抗KRAS2B, 抗KRAS4A, 抗KRAS4B, 抗RASK2, 抗v-Ki-ras2 Kirsten 大鼠肉瘤病毒癌基因同源物
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关于此项目
Conjugate:
unconjugated
Clone:
3B10-2F2, monoclonal
Application:
ELISA, ELISA (c), IF, WB
Citations:
57
产品名称
单克隆抗 KRAS 小鼠抗, clone 3B10-2F2, purified immunoglobulin, buffered aqueous solution
biological source
mouse
Quality Level
conjugate
unconjugated
antibody form
purified immunoglobulin
antibody product type
primary antibodies
clone
3B10-2F2, monoclonal
form
buffered aqueous solution
species reactivity
human
technique(s)
ELISA: suitable, capture ELISA: suitable, immunofluorescence: suitable, western blot: 1-5 μg/mL
isotype
IgG1κ
GenBank accession no.
UniProt accession no.
application(s)
research pathology
shipped in
dry ice
storage temp.
−20°C
target post-translational modification
unmodified
Gene Information
human ... KRAS(3845)
General description
Kirsten大鼠肉瘤病毒癌基因同源物（KRAS）是癌基因，映射至人12p12.1染色体。选择性剪接产生编码两个同工型变体，在C末端区域不同。该基因编码小GTP酶超家族的成员。
Immunogen
KRAS (AAH13572，1 a.a.~188 a.a) 带有 GST 标签的全长重组蛋白。仅 GST 标签的分子量为 26 kDa。
序列
MTEYKLVVVGAGGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGHEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQGVDDAFYTLVREIRKHKEKMSKDGKKKKKKSKTKCVIM
序列
MTEYKLVVVGAGGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGHEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQGVDDAFYTLVREIRKHKEKMSKDGKKKKKKSKTKCVIM
Application
小鼠抗 KRAS 单克隆抗体用于：免疫沉淀、免疫荧光、蛋白质印迹、 间接酶联免疫吸附测定（ELISA）。
Biochem/physiol Actions
Kirsten大鼠肉瘤病毒致癌基因同源物（KRAS）是Ras信号通路的关键蛋白。促进肿瘤侵袭和转移。该基因的功能获得性突变致使多种肿瘤发生，包括胰腺肿瘤、胆道肿瘤和结肠肿瘤。这种突变在胃癌中很少见到。
Physical form
磷酸盐缓冲盐溶液，pH 7.4
Legal Information
GenBank is a registered trademark of United States Department of Health and Human Services
Disclaimer
除非我们的产品目录或产品随附的其他公司文件中另有说明，否则我们的产品仅用于研究用途，不得用于任何其他目的，包括但不限于未经授权的商业用途、体外诊断用途、体外或体内治疗用途或任何类型的人类或动物消费或应用。
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存储类别
10 - Combustible liquids
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)
法规信息
常规特殊物品
低风险生物材料
此项目有
Atorvastatin overcomes gefitinib resistance in KRAS mutant human non-small cell lung carcinoma cells
Chen J, et al
Cell Death & Disease, 4(9), e814-e814 (2013)
MiR-384 inhibits human colorectal cancer metastasis by targeting KRAS and CDC42
Wang YX, et al.
Oncotarget, 7, 84826-84826 (2016)
Andrew M Waters et al.
PloS one, 11(9), e0163272-e0163272 (2016-09-30)
Synonymous mutations in the KRAS gene are clustered at G12, G13, and G60 in human cancers. We constructed 9 stable NIH3T3 cell lines expressing KRAS, each with one of these synonymous mutations. Compared to the negative control cell line expressing
全球贸易项目编号
| 货号 | GTIN |
|---|---|
| WH0003845M1-100UG | 04061837543333 |