WH0055288M1
抗-RHOT1单克隆抗体 小鼠抗
clone 4H4, purified immunoglobulin, buffered aqueous solution
别名:
抗- ras 同源基因族，成员T1, 抗-ARHT1, 抗-FLJ11040, 抗-FLJ12633, 抗-MIRO1
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关于此项目
NACRES:
NA.41
UNSPSC Code:
12352203
Conjugate:
unconjugated
Clone:
4H4, monoclonal
Application:
ELISA (i), WB
Citations:
9
biological source
mouse
Quality Level
conjugate
unconjugated
antibody form
purified immunoglobulin
antibody product type
primary antibodies
clone
4H4, monoclonal
form
buffered aqueous solution
species reactivity
human
technique(s)
indirect ELISA: suitable, western blot: 1-5 μg/mL
isotype
IgG1κ
GenBank accession no.
UniProt accession no.
shipped in
dry ice
storage temp.
−20°C
target post-translational modification
unmodified
Gene Information
human ... RHOT1(55288)
General description
Ras同源物家族成员T1（RHOT1）由位于人染色体 17q11.2的基因编码。RhoT1是线粒体Rho GTPase家族成员。
Immunogen
带GST标签的RHOT1（NP_060777，483 a.a. ~ 580 a.a）部分重组蛋白。GST标签的分子量为26 KDa。
序列
TEAEIICDVVCLVYDVSNPKSFEYCARIFKQHFMDSRIPCLIVAAKSDLHEVKQEYSISPTDFCRKHKMPPPQAFTCNTADAPSKDIFVKLTTMAMYP
序列
TEAEIICDVVCLVYDVSNPKSFEYCARIFKQHFMDSRIPCLIVAAKSDLHEVKQEYSISPTDFCRKHKMPPPQAFTCNTADAPSKDIFVKLTTMAMYP
Biochem/physiol Actions
Ras同源物家族成员T1（RHOT1）在线粒体稳态和细胞凋亡的控制中起着至关重要的作用。RHOT1 可作为胰腺癌（PC）的肿瘤抑制基因，它被认为是总体生存率的潜在预后生物标志物，也有望成为PC治疗靶点。RHOT1表达的下降可能导致淋巴结转移（LNM）和较短的生存期。RHOT1在线粒体运输、淋巴细胞迁移和极性中发挥重要作用。
Physical form
溶于pH7.4的磷酸盐缓冲盐水中的溶液
Legal Information
GenBank is a registered trademark of United States Department of Health and Human Services
Disclaimer
除非我们的产品目录或产品附带的其他公司文档另有说明，否则我们的产品仅供研究使用，不得用于任何其他目的，包括但不限于未经授权的商业用途、体外诊断用途、离体或体内治疗用途或任何类型的消费或应用于人类或动物。
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存储类别
10 - Combustible liquids
wgk
nwg
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)
法规信息
低风险生物材料
常规特殊物品
此项目有
Pei-I Tsai et al.
Molecular biology of the cell, 28(24), 3471-3479 (2017-09-15)
MIC60/mitofilin constitutes a hetero-oligomeric complex on the inner mitochondrial membranes to maintain crista structure. However, little is known about its physiological functions. Here, by characterizing
Renu Bajaj et al.
Molecular cytogenetics, 4, 3-3 (2011-01-22)
To evaluate the clinical validity of genome-wide oligonucleotide array comparative genomic hybridization (aCGH) for detecting somatic abnormalities, we have applied this genomic analysis to 30 cases (13 MDS and 17 AML) with clonal chromosomal abnormalities detected in more than 50%
RhoT1 and Smad4 are correlated with lymph node metastasis and overall survival in pancreatic cancer.
Hua Jiang et al.
PloS one, 7(7), e42234-e42234 (2012-08-04)
Cancer cell invasion and metastasis are the most important adverse prognostic factors for pancreatic cancer. Identification of biomarkers associated with outcome of pancreatic cancer may provide new approaches and targets for anticancer therapy. The aim of this study is to
全球贸易项目编号
| 货号 | GTIN |
|---|---|
| WH0055288M1-100UG | 04061832744230 |