X2252
黄嘌呤氧化酶 微生物
lyophilized powder, ≥7 units/mg solid
别名:
XO, 次黄嘌呤氧化酶, 黄嘌呤氧化酶, XOD, 黄嘌呤：氧化还原酶
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关于此项目
化学文摘社编号:
UNSPSC Code:
12352204
NACRES:
NA.54
EC Number:
232-657-6
MDL number:
Specific activity:
≥7 units/mg solid
Biological source:
microbial
biological source
microbial
Quality Level
form
lyophilized powder
specific activity
≥7 units/mg solid
mol wt
~160 kDa
technique(s)
inhibition assay: suitable
color
brown
optimum pH
7.5-8.0
shipped in
wet ice
storage temp.
−20°C
Gene Information
Escherichia coli K12 ... xdhA(947116), xdhB(947205), xdhC(945148)
General description
抑制剂：还原剂，Hg++，Ag+，MIA
最佳pH: 7.5 - 8.0
最佳温度：65oC
pH稳定性：pH 6.5 - 9.0 (25oC, 15hr)
温度稳定性：低于55oC (pH 8.0, 30min)
最佳pH: 7.5 - 8.0
最佳温度：65oC
pH稳定性：pH 6.5 - 9.0 (25oC, 15hr)
温度稳定性：低于55oC (pH 8.0, 30min)
研究领域：细胞周期
黄嘌呤氧化酶(XO)，一种多功能的含钼黄素蛋白，是黄嘌呤氧化还原酶(XORs)的形式之一。每个黄嘌呤氧化酶由2个黄素分子(FAD)、2个钼原子和8个铁原子构成。
黄嘌呤氧化酶(XO)，一种多功能的含钼黄素蛋白，是黄嘌呤氧化还原酶(XORs)的形式之一。每个黄嘌呤氧化酶由2个黄素分子(FAD)、2个钼原子和8个铁原子构成。
Application
黄嘌呤氧化酶（微生物）可用于：
- 测定体外黄嘌呤氧化酶活性
- 在超氧化物歧化酶检测中生成超氧阴离子
- 作为比色纸装置的反应混合液组分，酶法检测传统药物中的别嘌呤醇
Biochem/physiol Actions
还含有蛋白水解活性。
黄嘌呤氧化酶在嘌呤代谢中催化次黄嘌呤羟基化为黄嘌呤，黄嘌呤羟基化为尿酸和氧自由基。这种酶也参与咖啡因代谢。黄嘌呤氧化酶在药物等异源物质的代谢中也起重要作用，例如硫嘌呤类药物，涉及6-巯基嘌呤、别嘌呤醇和尿酸。黄嘌呤氧化酶活性过高会引起高尿酸血症（血中尿酸过多），进一步导致痛风。
Physical form
含有BSA和谷氨酸钠作为稳定剂的冻干粉末
Preparation Note
密闭。干燥。上锁保存或放置在只有经过授权或有资质的
人员才能进入的区域。
人员才能进入的区域。
Other Notes
在25 °C pH 7.5条件下，一个单位可在每分钟内将1.0 μ摩尔的黄嘌吟转化为尿酸。在次黄嘌呤作为底物时可获得约50%的活性。
signalword
Danger
hcodes
Hazard Classifications
Resp. Sens. 1
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
法规信息
常规特殊物品
含少量动物源组分生物产品
此项目有
实验方案
The appearance of uric acid is measured at 293nm by spectrophotometry.
P J Marro et al.
Pediatric research, 41(4 Pt 1), 513-520 (1997-04-01)
The effect of allopurinol to inhibit purine metabolism via the xanthine oxidase pathway in neonates with severe, progressive hypoxemia during rescue and reperfusion with extracorporeal membrane oxygenation (ECMO) was examined. Twenty-five term infants meeting ECMO criteria were randomized in a
Pál Pacher et al.
Pharmacological reviews, 58(1), 87-114 (2006-03-02)
The prototypical xanthine oxidase (XO) inhibitor allopurinol, has been the cornerstone of the clinical management of gout and conditions associated with hyperuricemia for several decades. More recent data indicate that XO also plays an important role in various forms of
Shyamal C Bir et al.
Journal of the American Heart Association, 1(5), e004093-e004093 (2013-01-15)
Hydrogen sulfide (H(2)S) therapy is recognized as a modulator of vascular function during tissue ischemia with the notion of potential interactions of nitric oxide (NO) metabolism. However, little is known about specific biochemical mechanisms or the importance of H(2)S activation
全球贸易项目编号
| 货号 | GTIN |
|---|---|
| X2252-100UN | 04061837545238 |
| X2252-25UN | 04061837545245 |