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Y102

YC-1

Name: YC-1
Brand: SIGMA

soluble guanylyl cyclase activator, powder

别名:

3-(5′-羟甲基-2′-呋喃基）-1-苄基吲唑

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关于此项目

经验公式（希尔记法）:

C₁₉H₁₆N₂O₂

化学文摘社编号:

170632-47-0

分子量:

304.34

UNSPSC Code:

41106305

PubChem Substance ID:

24278782

NACRES:

NA.77

MDL number:

MFCD06407798

Form:

powder

Quality level:

200

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属性

产品名称

YC-1, powder

form

powder

Quality Level

200

color

white to yellow

solubility

DMSO: 10 mg/mL, H₂O: insoluble

SMILES string

OCc1ccc(o1)-c2nn(Cc3ccccc3)c4ccccc24

InChI

1S/C19H16N2O2/c22-13-15-10-11-18(23-15)19-16-8-4-5-9-17(16)21(20-19)12-14-6-2-1-3-7-14/h1-11,22H,12-13H2

InChI key

OQQVFCKUDYMWGV-UHFFFAOYSA-N

Gene Information

human ... PDE5A(8654)

说明

Application

Yc-1作为缺氧诱导因子1α （HIF-1α）抑制剂，用于：

减少心肌细胞（CM）中缺氧诱导Jagged1的表达
研究其对祖细胞扩增、CD34 +和侧群（SP）细胞表型的影响，以及对有能力形成长期菌落形成单位细胞增殖率的影响
通过激活Rho / Rho相关蛋白激酶（ROCK）途径，研究其调节对与白蛋白诱导的纤溶酶原激活物抑制剂1（PAI-1）表达结合的1-磷酸鞘氨醇（S1P）表达的调节作用。

Biochem/physiol Actions

YC-1激活可溶性鸟苷酸环化酶，防止血小板聚集和血管收缩。具有治疗循环系统疾病的潜力。Yc-1还具有在体外抑制缺氧诱导因子1α （HIF-1α）活性的能力。可作为潜在的抗血管生成抗癌剂。

可溶性鸟苷酸环化酶的 NO（一氧化氮）非依赖性激活剂。

Features and Benefits

这种化合物是环核苷酸研究的特色产品。点击此处发现更多特色环核苷酸产品。在sigma.com/discover-bsm可了解更多关于生物活性小分子的其他研究领域。

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存储类别

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

历史批次信息供参考:

分析证书(COA)

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商品

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Cyclic nucleotides like cAMP modulate cell function via PKA activation and ion channels.

Insufficient radiofrequency ablation promotes angiogenesis of residual hepatocellular carcinoma via HIF-1α/VEGFA.

Jian Kong et al.

PloS one, 7(5), e37266-e37266 (2012-05-23)

The mechanism of rapid growth of the residual tumor after radiofrequency (RF) ablation is poorly understood. In this study, we investigated the effect of hyperthermia on HepG2 cells and generated a subline with enhanced viability and dys-regulated angiogenesis in vivo

Low-dose YC-1 combined with glucose and insulin selectively induces apoptosis in hypoxic gastric carcinoma cells by inhibiting anaerobic glycolysis.

Kota Wakiyama et al.

Scientific reports, 7(1), 12653-12653 (2017-10-06)

This study aimed to establish a therapeutic strategy targeting hypoxic cancer cells in gastric carcinoma (GC). YC-1 is a HIF-1α inhibitor, and we revealed that low-dose YC-1 (10 µM) suppressed HIF-1α expression, and induced hypoxia-dependent apoptosis in the GC cell line

Sub-sets of cancer stem cells differ intrinsically in their patterns of oxygen metabolism.

Luke Gammon et al.

PloS one, 8(4), e62493-e62493 (2013-05-03)

The glycolytic response of hypoxic cells is primarily mediated by the hypoxia inducible factor alpha (HIF-1α) but even in the presence of abundant oxygen tumours typically show high rates of glycolysis. Higher levels of HIF-1α in tumours are associated with

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全球贸易项目编号

货号	GTIN
Y102-25MG	04061837587825
Y102-5MG	04061832900803