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Z0878

敏喘宁

cGMP-specific phosphodiesterases V and VI inhibitor, solid

别名:

1,4-二氢-5-（2-丙氧苯基）-7H-1,2,3-三唑并 (4,5-d) 嘧啶-7-酮

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关于此项目

经验公式（希尔记法）:
C13H13N5O2
化学文摘社编号:
37762-06-4
分子量:
271.27
NACRES:
NA.77
PubChem Substance ID:
24278072
UNSPSC Code:
12352202
EC Number:
253-655-1
MDL number:
MFCD00214073
Form:
solid
Quality level:
200
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产品名称

敏喘宁, solid

form

solid

Quality Level

200

color

white

solubility

45% (w/v) aq 2-hydroxypropyl-β-cyclodextrin: 0.11 mg/mL, DMSO: 10 mg/mL, H2O: insoluble

SMILES string

CCCOc1ccccc1C2=NC(=O)c3nn[nH]c3N2

InChI

1S/C13H13N5O2/c1-2-7-20-9-6-4-3-5-8(9)11-14-12-10(13(19)15-11)16-18-17-12/h3-6H,2,7H2,1H3,(H2,14,15,16,17,18,19)

InChI key

REZGGXNDEMKIQB-UHFFFAOYSA-N

Gene Information

human ... PDE2A(5138), PDE4A(5141), PDE4B(5142), PDE4D(5144)

Application

扎普司特已被用于通过生发泡破裂（GVBD）检测测定其对卵母细胞减数分裂的影响，并用于通过免疫组织化学测试其对视网膜细胞的抑制作用。

Biochem/physiol Actions

扎普司特对磷酸二酯酶10和11（PDE10和PDE11）没有实质性的抑制作用。它还具有血管舒张作用。
cGMP 特异性磷酸二酯酶 V 和 VI (PDE5/6) 选择性抑制剂和 G 蛋白偶联受体 35 (GPR35) 激动剂。

pictograms

Exclamation mark
GHS07

signalword

Warning

Hazard Classifications

Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

target_organs

Respiratory system

存储类别

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

dust mask type N95 (US), Eyeshields, Gloves

历史批次信息供参考:

分析证书(COA)

Lot/Batch Number
13181102
029M4114V
078M4149V
13180405
048M4089V

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Xinhua Zhang et al.
American journal of physiology. Endocrinology and metabolism, 302(2), E243-E253 (2011-10-27)
Testosterone (T) plays a permissive role in the development of benign prostatic hyperplasia (BPH), and phosphodiesterase 5 inhibitors (PDE5is) have been found to be effective for BPH and lower urinary tract symptoms (LUTS) in clinical trials. This study investigated the
Cristina Cosi et al.
Neuropharmacology, 60(7-8), 1227-1231 (2010-11-30)
G-protein coupled receptor 35 (GPR35) is a former "orphan receptor" expressed in brain and activated by either kynurenic acid or zaprinast. While zaprinast has been studied as a phosphodiesterase inhibitor, kynurenic acid (KYNA) is a tryptophan metabolite and has been
P Calabresi et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 19(7), 2489-2499 (1999-03-23)
High-frequency stimulation (HFS) of corticostriatal glutamatergic fibers induces long-term depression (LTD) of excitatory synaptic potentials recorded from striatal spiny neurons. This form of LTD can be mimicked by zaprinast, a selective inhibitor of cGMP phosphodiesterases (PDEs). Biochemical analysis shows that
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全球贸易项目编号

货号GTIN
Z0878-25MG04061832950082
Z0878-100MG04061832950075