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Merck
CN

1009005

USP

乙酰半胱氨酸

United States Pharmacopeia (USP) Reference Standard

别名:

N-乙酰基-L-半胱氨酸, LNAC, NAC

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关于此项目

线性分子式:
HSCH2CH(NHCOCH3)CO2H
化学文摘社编号:
分子量:
163.19
UNSPSC Code:
41116107
NACRES:
NA.24
PubChem Substance ID:
MDL number:
Beilstein/REAXYS Number:
1724426
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grade

pharmaceutical primary standard

API family

acetylcysteine

manufacturer/tradename

USP

mp

106-108 °C (lit.)

application(s)

pharmaceutical (small molecule)

format

neat

storage temp.

2-8°C

SMILES string

CC(=O)N[C@@H](CS)C(O)=O

InChI

1S/C5H9NO3S/c1-3(7)6-4(2-10)5(8)9/h4,10H,2H2,1H3,(H,6,7)(H,8,9)/t4-/m0/s1

InChI key

PWKSKIMOESPYIA-BYPYZUCNSA-N

General description

本品按现行药典规定交付。所有为支持本产品而提供的信息,包括SDS和任何产品信息单均由药典颁发机构制定并发布。如需进一步信息和支持,请访问现行药典网站。

Application

乙酰半胱氨酸USP参考标准品用于指定的药典测试和检测。

也用于制备标准储备溶液和标准溶液,用于根据美国药典各论的规定通过液相色谱法和紫外检测器进行检测。
  • 乙酰半胱氨酸溶液
  • 乙酰半胱氨酸
  • 乙酰半胱氨酸复合溶液

Biochem/physiol Actions

抗氧化剂和黏液溶解剂(mucolytic agent)。增加细胞池的自由基清除剂。 据报道可防止神经细胞凋亡,但会诱导平滑肌细胞凋亡。抑制HIV复制。可作为微粒体谷胱甘肽转移酶的底物。

Analysis Note

这些产品仅供测试和分析使用。它们不适用于人类或动物的给药,不可用于诊断、治疗或治愈任何疾病。  ?

Other Notes

可能会涉及到销售限制。


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signalword

Warning

hcodes

Hazard Classifications

Eye Irrit. 2

flash_point_f

Not applicable

flash_point_c

Not applicable

存储类别

11 - Combustible Solids



历史批次信息供参考:

分析证书(COA)

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Acetylcysteine Solution
United States Pharmacopeia and National Formulary
United States Pharmacopeia, 27(3), 82-82 (2020)
Yuval Samuni et al.
Biochimica et biophysica acta, 1830(8), 4117-4129 (2013-04-27)
N-acetylcysteine (NAC) has been in clinical practice for several decades. It has been used as a mucolytic agent and for the treatment of numerous disorders including paracetamol intoxication, doxorubicin cardiotoxicity, ischemia-reperfusion cardiac injury, acute respiratory distress syndrome, bronchitis, chemotherapy-induced toxicity
Anna M Sadowska
Therapeutic advances in respiratory disease, 6(3), 127-135 (2012-03-01)
To develop an efficient therapy for chronic obstructive pulmonary disease (COPD), N-acetylcysteine (NAC) has been tested as a medication that can suppress various pathogenic processes in this disease. NAC is a thiol compound, which provides sulfhydryl groups. NAC can act



全球贸易项目编号

货号GTIN
1009005-200MG04061838664631