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1040683

USP

芹菜素

Name: 芹菜素
Brand: USP

United States Pharmacopeia (USP) Reference Standard

别名:

4 & # 8242;,5,7-三羟基黄酮, 5,7-二羟基-2-（4-羟基苯基）-4-苯并吡喃酮

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关于此项目

经验公式（希尔记法）:

C₁₅H₁₀O₅

化学文摘社编号:

520-36-5

分子量:

270.24

UNSPSC Code:

41116107

NACRES:

NA.24

PubChem Substance ID:

329749048

MDL number:

MFCD00006831

Beilstein/REAXYS Number:

262620

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属性

grade

pharmaceutical primary standard

API family

apigenin

manufacturer/tradename

USP

mp

>300 °C (lit.)

application(s)

pharmaceutical (small molecule)

format

neat

storage temp.

−20°C

SMILES string

Oc1ccc(cc1)C2=CC(=O)c3c(O)cc(O)cc3O2

InChI

1S/C15H10O5/c16-9-3-1-8(2-4-9)13-7-12(19)15-11(18)5-10(17)6-14(15)20-13/h1-7,16-18H

InChI key

KZNIFHPLKGYRTM-UHFFFAOYSA-N

说明

General description

Flavonoids belong to polyphenolic class of compounds. They play crucial role in biological activities which include tumor growth inhibition and chemoprevention. Apigenin is a plant flavonoid mostly used to inhibit ornithine decarboxylase activity and skin tumor.

Application

Apigenin USP reference standard, intended for use in specified quality tests and assays as specified in the USP compendia. Also, for use with USP monographs such as:

Powdered Soy Isoflavones Extract
Soy Isoflavones Capsules
Soy Isoflavones Tablets

Biochem/physiol Actions

一种植物类黄酮，研究发现它通过在G₂/M阶段阻止细胞周期来抑制细胞增殖。通过细胞周期停滞和诱导凋亡来抑制生长似乎与p53的诱导有关。对肿瘤促进的抑制作用也可能是由于激酶活性的抑制以及由此导致的癌基因表达的抑制。研究还报道了抑制拓扑异构酶ⅰ催化的脱氧核糖核酸再附着和增强细胞间缝隙连接通讯。

一种植物类黄酮，研究发现它通过在G₂/M阶段阻止细胞周期来抑制细胞增殖。通过细胞周期停滞和诱导凋亡来抑制生长似乎与p53的诱导有关。通过抑制蛋白激酶C和由此导致的癌基因表达抑制来抑制PMA介导的肿瘤促进。研究还报道了抑制拓扑异构酶ⅰ催化的脱氧核糖核酸再连接和增强间隙连接细胞间通讯。

Analysis Note

These products are for test and assay use only. They are not meant for administration to humans or animals and cannot be used to diagnose, treat, or cure diseases of any kind.

Other Notes

Sales restrictions may apply.

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存储类别

11 - Combustible Solids

历史批次信息供参考:

分析证书(COA)

Lot/Batch Number

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Flavonoids apigenin and quercetin inhibit melanoma growth and metastatic potential.

Caltagirone S

International Journal of Cancer. Journal International Du Cancer, 87(4), 595-600 (2000)

Inhibition of ultraviolet light induced skin carcinogenesis in SKH-1 mice by apigenin, a plant flavonoid.

Birt DF

Anticancer Research, 17(1A), 85-91 (1997)

Identification of puerarin and its metabolites in rats by liquid chromatography-tandem mass spectrometry.

Prasain JK

Journal of Agricultural and Food Chemistry, 52(12), 3708-3712 (2004)

全球贸易项目编号

货号	GTIN
1040683-30MG	04061833840023