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1353500

USP

异维甲酸

Name: 异维甲酸
Brand: USP

United States Pharmacopeia (USP) Reference Standard

别名:

13-顺式-维甲酸, 13-顺式-维A酸, 异维甲酸

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关于此项目

经验公式（希尔记法）:

C₂₀H₂₈O₂

化学文摘社编号:

4759-48-2

分子量:

300.44

NACRES:

NA.24

PubChem Substance ID:

329750208

UNSPSC Code:

41116107

MDL number:

MFCD00079542

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属性

grade

pharmaceutical primary standard

API family

isotretinoin

manufacturer/tradename

USP

mp

172-175 °C (lit.)

application(s)

pharmaceutical (small molecule)

format

neat

SMILES string

[H]\C(C(O)=O)=C(C)\C=C\C=C(C)\C=C\C1=C(C)CCCC1(C)C

InChI

1S/C20H28O2/c1-15(8-6-9-16(2)14-19(21)22)11-12-18-17(3)10-7-13-20(18,4)5/h6,8-9,11-12,14H,7,10,13H2,1-5H3,(H,21,22)/b9-6+,12-11+,15-8+,16-14-

InChI key

SHGAZHPCJJPHSC-XFYACQKRSA-N

Gene Information

human ... RARA(5914), RARB(5915), RARG(5916)

说明

General description

本品按现行药典规定交付。所有为支持本产品而提供的信息，包括SDS和任何产品信息单均由药典颁发机构制定并发布。如需进一步信息和支持，请访问现行药典网站。

Application

异维甲酸USP参考标准品，预期用途是USP规定的指定质量测试和检测。也用于USP各论，例如：

异维甲酸胶囊
维甲酸

Biochem/physiol Actions

13-顺式维甲酸(RA)具有抗炎、抗肿瘤作用。RA的作用通过RAR-β和RAR-α受体介导。RA可减弱细胞因子刺激小鼠系膜细胞iNOS的表达和活性。它诱导线粒体膜通透性转变，表现为肿胀和膜电位下降，并通过凋亡途径刺激细胞色素C的释放。这些活性被EGTA和环孢素A逆转。RA也通过增加转录部分增加MMP-1蛋白的表达。

Analysis Note

这些产品仅供测试和分析使用。它们不适用于人类或动物的给药，不可用于诊断、治疗或治愈任何疾病。

Other Notes

可能适用相应的销售限制。

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signalword

Danger

target_organs

Respiratory system

存储类别

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

flash_point_f

Not applicable

flash_point_c

Not applicable

Hazard Classifications

Aquatic Acute 1 - Aquatic Chronic 1 - Eye Irrit. 2 - Repr. 1B - Skin Irrit. 2 - STOT SE 3

历史批次信息供参考:

分析证书(COA)

Lot/Batch Number

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Isotretinoin

United States Pharmacopeia, 2457-2457 (2020)

Clinical relevance of skin barrier changes associated with the use of oral isotretinoin: the importance of barrier repair therapy in patient management.

James Q Del Rosso

Journal of drugs in dermatology : JDD, 12(6), 626-631 (2013-07-11)

Oral isotretinoin is a non-aromatic oral retinoid that is highly effective for the treatment of severe inflammatory acne vulgaris that is refractory and/or prone to scarring, and has also been used successfully to treat several other disorders in selected cases.

The role of isotretinoin in acne therapy: why not as first-line therapy? facts and controversies.

Dimitris Rigopoulos et al.

Clinics in dermatology, 28(1), 24-30 (2010-01-20)

Acne is one of the most prevalent diseases in dermatology: Millions of people worldwide experience this distressing condition. To determine the appropriate therapeutic strategy, there is a strong need for a standardized classification system of acne. The exact molecular mechanism

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全球贸易项目编号

货号	GTIN
1353500-200MG	04061838730633