V900429
N-乙酰基-L-半胱氨酸
98%, Vetec™
别名:
LNAC, NAC
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关于此项目
线性分子式:
HSCH2CH(NHCOCH3)CO2H
化学文摘社编号:
分子量:
163.19
UNSPSC Code:
12352209
PubChem Substance ID:
EC Number:
210-498-3
Beilstein/REAXYS Number:
1724426
MDL number:
产品名称
N-乙酰基-L-半胱氨酸, Vetec™, reagent grade, 98%
grade
reagent grade
product line
Vetec™
assay
98%
form
powder
color
white to off-white
mp
106-108 °C (lit.)
application(s)
cell analysis
storage temp.
2-8°C
SMILES string
CC(=O)N[C@@H](CS)C(O)=O
InChI
1S/C5H9NO3S/c1-3(7)6-4(2-10)5(8)9/h4,10H,2H2,1H3,(H,6,7)(H,8,9)/t4-/m0/s1
InChI key
PWKSKIMOESPYIA-BYPYZUCNSA-N
Application
- 抗氧化检测方法开发：N-乙酰-L-半胱氨酸(NAC)参与CYP3A介导的芦竹碱细胞的代谢激活和毒性评估，反应它在氧化应激生化分析中的重要性，是IVD试剂开发的重要参考因素(Gao et al., 2024)。
- 细胞分化和NF-κB抑制：本文中，乙酰半胱氨酸又有不同的作用，它可诱导氧化应激和抑制NF-κB通路，对急性髓系白血病(AML)治疗细胞的分化起重要作用。表明乙酰半胱氨酸可用于癌症治疗和研究的临床诊断试剂中(Silva et al., 2024)。
- 肝损伤治疗：用乙酰半胱氨酸缓解对乙酰氨基酚过量引起的肝损伤，体现其临床应用潜力和开发IVD治疗检测产品的用途(Chen et al., 2024)。
- 提高癌症疗效：乙酰半胱氨酸用于联合治疗胃后(posterior gastric)腹膜假黏液瘤，可作为生化药物提高癌症治疗功效，适于诊断和治疗应用(Sun et al., 2024)。
- 细胞周期和自噬调节：乙酰半胱氨酸可与1-甲氧基异芸苔素(Methoxyisobrassinin)在卵巢癌细胞中相互作用调节细胞周期、凋亡和自噬，体现它开发生物标志物检测等IVD产品的作用(Zigová et al., 2024)。
Biochem/physiol Actions
抗氧化剂和黏液溶解剂(mucolytic agent)。增加细胞池的自由基清除剂。 据报道可防止神经细胞凋亡，但会诱导平滑肌细胞凋亡。抑制HIV复制。可作为微粒体谷胱甘肽转移酶的底物。
Legal Information
Vetec is a trademark of Merck KGaA, Darmstadt, Germany
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signalword
Warning
hcodes
Hazard Classifications
Eye Irrit. 2
存储类别
13 - Non Combustible Solids
wgk
WGK 2
flash_point_f
Not applicable
flash_point_c
Not applicable
Suzanne M Cloonan et al.
Journal of medicinal chemistry, 58(11), 4494-4505 (2015-05-12)
Ruthenium polypyridyl complexes show great promise as new photodynamic therapy (PDT) agents. However, a lack of detailed understanding of their mode of action in cells poses a challenge to their development. We have designed a new Ru(II) PDT candidate that
Yuval Samuni et al.
Biochimica et biophysica acta, 1830(8), 4117-4129 (2013-04-27)
N-acetylcysteine (NAC) has been in clinical practice for several decades. It has been used as a mucolytic agent and for the treatment of numerous disorders including paracetamol intoxication, doxorubicin cardiotoxicity, ischemia-reperfusion cardiac injury, acute respiratory distress syndrome, bronchitis, chemotherapy-induced toxicity
Luigi Franchi et al.
Journal of immunology (Baltimore, Md. : 1950), 193(8), 4214-4222 (2014-09-17)
The nucleotide-binding oligomerization domain-like receptor pyrin domain-containing 3 (Nlrp3) inflammasome plays an important role in inflammation by controlling the maturation and secretion of the cytokines IL-1β and IL-18 in response to multiple stimuli including pore-forming toxins, particulate matter, and ATP.
全球贸易项目编号
| 货号 | GTIN |
|---|---|
| V900429-25G | 04061833462225 |
| V900429-100G | 04061833470039 |