V900497
胃蛋白酶 来源于猪胃粘膜
Vetec™, reagent grade
别名:
胃液素 来源于猪胃, 胃蛋白酶 A
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关于此项目
化学文摘社编号:
UNSPSC Code:
12352204
EC Number:
232-629-3
MDL number:
Specific activity:
400-800 units/mg protein
grade
reagent grade
product line
Vetec™
form
solid
specific activity
400-800 units/mg protein
mol wt
35 kDa
Application
胃蛋白酶切割可用于产生抗体的F(ab′)2 片段。有关胃蛋白酶的更多信息，请访问 www.sigma-aldrich.com/enzymeexplorer。
Biochem/physiol Actions
优先裂解：P1 和 P1′ 位的疏水性和芳族残基。降解胰岛素 β 链中的 Phe-Val、Gln-His、Glu-Ala、Ala-Leu、Leu-Tyr、Tyr-Leu、Gly-Phe、Phe-Phe 和 Phe-Tyr 键
Analysis Note
最适pH值为2-4。在4 M尿素和3 M盐酸胍中可保持活性。在60°C时稳定。胃蛋白酶在pH 8.0-8.5下发生不可逆灭活。
Other Notes
用血红蛋白作为底物，对TCA可溶性产物进行测定，在pH2.0，37℃条件下，一个单位每分钟可产生0.001 A280。
Legal Information
Vetec is a trademark of Merck KGaA, Darmstadt, Germany
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signalword
Danger
hcodes
Hazard Classifications
Eye Irrit. 2 - Resp. Sens. 1 - Skin Irrit. 2 - STOT SE 3
target_organs
Respiratory system
存储类别
11 - Combustible Solids
wgk
WGK 1
flash_point_f
Not applicable
flash_point_c
Not applicable
法规信息
低风险生物材料
此项目有
Chuan-Hsiao Han et al.
Food chemistry, 138(2-3), 923-930 (2013-02-16)
Our previous report showed that yam dioscorin and its peptic hydrolysates exhibit radical scavenging activities; however, the functions of these peptic hydrolases are still under investigation. In this study, the thiol-containing peptides derived from computer-aided simulation of pepsin hydrolysis of
Shenlin Wang et al.
The Journal of biological chemistry, 289(2), 697-707 (2013-11-23)
Multidomain protein folding is often more complex than a two-state process, which leads to the spontaneous folding of the native state. Pepsin, a zymogen-derived enzyme, without its prosegment (PS), is irreversibly denatured and folds to a thermodynamically stable, non-native conformation
M N James et al.
Nature, 319(6048), 33-38 (1986-01-02)
The only well-understood mechanism of zymogen activation is that of the serine proteinases, in which proteolytic cleavage leads to conformational changes resulting in a functional active site. A different mechanism is now unveiled by the crystal structure of pepsinogen. Salt
全球贸易项目编号
| 货号 | GTIN |
|---|---|
| V900497-100G | 04061832708706 |
| V900497-500G | 04061832708713 |