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V900931

曲古抑菌素A

Name: 曲古抑菌素A
Brand: VETEC

From Streptomyces sp., ≥98%, HDAC inhibitor

别名:

曲古抑菌素A, TSA, [R-(E,E)]-7-[4-（二甲氨基）苯基]-N-羟基-4,6-二甲基-7-氧代-2,4-庚二烯酰胺

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关于此项目

经验公式（希尔记法）:

C₁₇H₂₂N₂O₃

化学文摘社编号:

58880-19-6

分子量:

302.37

PubChem Substance ID:

329830233

UNSPSC Code:

12352200

MDL number:

MFCD03848392

Assay:

≥98%

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属性

产品名称

曲古抑菌素A , Vetec^™, reagent grade, from Streptomyces sp., ≥98%

biological source

Streptomyces sp.

grade

reagent grade

product line

Vetec^™

assay

≥98%

storage temp.

−20°C

SMILES string

C[C@H](\C=C(C)\C=C\C(=O)NO)C(=O)c1ccc(cc1)N(C)C

InChI

1S/C17H22N2O3/c1-12(5-10-16(20)18-22)11-13(2)17(21)14-6-8-15(9-7-14)19(3)4/h5-11,13,22H,1-4H3,(H,18,20)/b10-5+,12-11+/t13-/m1/s1

InChI key

RTKIYFITIVXBLE-QEQCGCAPSA-N

说明

Biochem/physiol Actions

曲古抑菌素A(TSA)可抑制纳摩浓度的组蛋白脱乙酰基酶造成组蛋白高度乙酰化，使得染色质松弛并调节基因表达。可能参与多种细胞类型细胞周期过程，诱导G和G/M期细胞生长停滞；可能诱导细胞凋亡。增强靶向DNA的抗癌症剂的效力。曲古抑菌素A可作为表观遗传修饰剂。

曲古抑菌素A可抑制纳摩浓度的组蛋白脱乙酰基酶；组蛋白高乙酰化生成物会导致染色质弛豫并调节基因表达。

Legal Information

Vetec is a trademark of Merck KGaA, Darmstadt, Germany

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存储类别

11 - Combustible Solids

wgk

WGK 3

历史批次信息供参考:

分析证书(COA)

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全球贸易项目编号

货号	GTIN
V900931-1MG	04061826746073
V900931-5MG	04061826746080