108448
Cyanoacetamide
99%
Synonym(s):
2-Cyanoacetamide
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About This Item
Linear Formula:
NCCH2CONH2
CAS Number:
Molecular Weight:
84.08
UNSPSC Code:
12352100
NACRES:
NA.22
PubChem Substance ID:
EC Number:
203-531-8
Beilstein/REAXYS Number:
878221
MDL number:
Quality Level
assay
99%
mp
119-121 °C (lit.)
solubility
cold water: soluble 1gm in 6.5ml
functional group
amide, nitrile
SMILES string
NC(=O)CC#N
InChI
1S/C3H4N2O/c4-2-1-3(5)6/h1H2,(H2,5,6)
InChI key
DGJMPUGMZIKDRO-UHFFFAOYSA-N
General description
Cyanoacetamide is the starting reagent for vitamin B6 synthesis. It reacts with reducing carbohydrates in borate buffer to give intense fluorescence andis useful for the automated analysis of carbohydrates as borate complexes.
Cyanoacetamide is a highly reactive compound used as a reaction intermediate in condensation and substitution reactions.
Cyanoacetamide is a highly reactive compound used as a reaction intermediate in condensation and substitution reactions.
Application
Cyanoacetamide was used in spectrofluorimetric method for the determination of some antihistaminic H1 receptor antagonist drugs such as ebastine, cetirizine dihydrochloride and fexofenadine hydrochloride. It may be used in fluorometric determination of 3,4-dihydroxyphenylalanine. It was used as post column fluorigenic derivatizing agent for the bio-analysis and pharmacokinetics of chitosan ester in rabbit serum.
signalword
Warning
hcodes
Hazard Classifications
Acute Tox. 4 Oral - Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
target_organs
Respiratory system
Storage Class
11 - Combustible Solids
wgk
WGK 2
flash_point_f
419.0 °F - closed cup
flash_point_c
215 °C - closed cup
ppe
dust mask type N95 (US), Eyeshields, Gloves
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Articles
Knoevenagel Condensation is an organic reaction named after Emil Knoevenagel. It is a classic C-C bond formation reaction and a modification of the Aldol Condensation.
Hao Chen et al.
Scientific reports, 8(1), 13433-13433 (2018-09-09)
Early damage to transplanted organs initiates excess inflammation that can cause ongoing injury, a leading cause for late graft loss. The endothelial glycocalyx modulates immune reactions and chemokine-mediated haptotaxis, potentially driving graft loss. In prior work, conditional deficiency of the
Fluorimetric determination of reducing carbohydrates with 2-cyanoacetamide and application to automated analysis of carbohydrates as borate complexes.
Honda S, et al.
Analytical Chemistry, 52(7), 1079-1082 (1980)
Fluorometric determination of 3, 4-dihydroxyphenylalanine with 2-cyanoacetamide.
Liu Y, et al.
Journal of Fluorescence, 13(2), 123-128 (2003)
Global Trade Item Number
| SKU | GTIN |
|---|---|
| 108448-100G | 04061838685940 |
| 108448-500G | 04061838685957 |