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159034

Acetohydroxamic acid

Name: Acetohydroxamic acid
Brand: ALDRICH

98%

Synonym(s):

AHA

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About This Item

Linear Formula:

CH₃CONHOH

CAS Number:

546-88-3

Molecular Weight:

75.07

UNSPSC Code:

12352100

NACRES:

NA.22

PubChem Substance ID:

24849786

EC Number:

208-913-8

Beilstein/REAXYS Number:

1739019

MDL number:

MFCD00009994

Assay:

98%

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Properties

Quality Level

100

assay

98%

mp

88-90 °C (lit.)

functional group

amine

SMILES string

CC(NO)=O

InChI

1S/C2H5NO2/c1-2(4)3-5/h5H,1H3,(H,3,4)

InChI key

RRUDCFGSUDOHDG-UHFFFAOYSA-N

Gene Information

human ... CA2(760), MMP3(4314)

Description

General description

Acetohydroxamic acid is a potent inhibitor of bacterial urease activity and reduces urinary ammonia levels. 2-Acetohydroxamic acid loaded floating microspheres forms an efficient drug delivery system for the treatment of Helicobacter pylori.

Application

Acetohydroxamic acid was used:

to study the mechanism of complexation of iron (III) with acetohydroxamic acid
to study the inhibitory mechanism of lansoprazole and omeprazole on Helicobacter pyloni
in urease inhibition studies
for in situ generation of nitrosocarbonylmethane as a Diels-Alder dienophile

Used in urease inhibition studies and for in situ generation of nitrosocarbonylmethane as a Diels-Alder dienophile.

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pictograms

GHS08

signalword

Danger

hcodes

H360

pcodes

P201 - P308 + P313

Hazard Classifications

Repr. 1B

Storage Class

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

wgk

WGK 3

ppe

Eyeshields, Gloves, type P2 (EN 143) respirator cartridges

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Potent inhibitory action of the gastric proton pump inhibitor lansoprazole against urease activity of Helicobacter pylori: unique action selective for H. pylori cells.

K Nagata et al.

Antimicrobial agents and chemotherapy, 37(4), 769-774 (1993-04-01)

The gastric proton pump inhibitor lansoprazole, its active analog AG-2000, and omeprazole dose dependently inhibited urease activity extracted with distilled water from Helicobacter pylori cells; the 50% inhibitory concentrations were between 3.6 and 9.5 microM, which were more potent than

Zbl. Bakt., 275, 63-63 (1991)

A randomized trial of acetohydroxamic acid for the treatment and prevention of infection-induced urinary stones in spinal cord injury patients.

D P Griffith et al.

The Journal of urology, 140(2), 318-324 (1988-08-01)

Acetohydroxamic acid is known to inhibit bacterial urease activity, thus, reducing urinary ammonia levels. A double-blind placebo-controlled clinical trial of acetohydroxamic acid was conducted at 12 Veterans Administration spinal cord injury units. A total of 210 male spinal cord injury

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Global Trade Item Number

SKU	GTIN
159034-10G	04061832106182
159034-50G	04061832106199
159034-5G	04061838744333