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Merck
CN

184314

Tetrahydrofuran-d8

≥99.5 atom % D

Synonym(s):

THF-d8, Deuterated tetrahydrofuran, Octadeuterotetrahydrofuran

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About This Item

Empirical Formula (Hill Notation):
C4D8O
CAS Number:
Molecular Weight:
80.16
UNSPSC Code:
12142201
NACRES:
NA.21
PubChem Substance ID:
MDL number:
Beilstein/REAXYS Number:
111854
Isotopic purity:
≥99.5 atom % D
Assay:
≥99% (CP)
Mass shift:
M+8
Form:
liquid
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isotopic purity

≥99.5 atom % D

Quality Level

assay

≥99% (CP)

form

liquid

technique(s)

NMR: suitable

impurities

≤0.03% water
water

refractive index

n20/D 1.403 (lit.)

bp

65-66 °C (lit.)

mp

−106 °C (lit.)

density

0.985 g/mL at 25 °C (lit.)

mass shift

M+8

storage temp.

2-8°C

SMILES string

[2H]C1([2H])OC([2H])([2H])C([2H])([2H])C1([2H])[2H]

InChI

1S/C4H8O/c1-2-4-5-3-1/h1-4H2/i1D2,2D2,3D2,4D2

InChI key

WYURNTSHIVDZCO-SVYQBANQSA-N

General description

Tetrahydrofuran-d8 (THF-d8), a deuterated derivative of tetrahydrofuran, is a standard purity solvent suitable for routine NMR analyses (conducted at ambient temperatures where quality is less critical). It participates as a solvent in an intermolecular proton exchange reaction between methanol and acetic acid. Kinetics of this reaction has been studied by ′H NMR line shape analysis. Infrared spectral studies of THF and THF-d8 have been investigated in the range of 10 and 300cm-1.
Tetrahydrofuran-d8 may be used as a solvent in the synthesis of deuteriotris[bis(trimethylsilyl)amido]thorium and deuteriotris[bis(trimethylsiiyl)amido]uranium.

Other Notes

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signalword

Danger

Hazard Classifications

Acute Tox. 4 Oral - Carc. 2 - Eye Irrit. 2 - Flam. Liq. 2 - STOT SE 3

target_organs

Respiratory system

supp_hazards

Storage Class

3 - Flammable liquids

wgk

WGK 1

flash_point_f

1.4 °F - closed cup

flash_point_c

-17 °C - closed cup

Regulatory Information

危险化学品
美国出口管控产品

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Articles

Use this reference table to find the coupling values and chemical shifts of our NMR (deuterated) solvents. Melting and boiling points, molecular weight, density, and CAS number are also listed.

Related Content

默克分享核磁共振波谱法是一种测定样本分子结构和化学成分的分析技术,主要分析自旋原子核和强磁场之间的相互作用。其工作原理是外加静磁场引起分子中的特定原子核选择性吸收射频,通过所吸收的能量诱导核自旋的跃迁并呈现在共振谱上。

NMR spectroscopy elucidates molecular structure and purity via nuclear spin states in a strong magnetic field.


Far-Infrared Spectrum of Tetrahydrofuran: Spectroscopic Evidence for Pseudorotation.
Lafferty WJ, et al.
J. Chem. Phys. , 42(8), 2915-2919 (1965)
Dynamic NMR study of the interference between cyclic proton exchange, selfassociation and hindered rotation of diphenylformamidine in tetrahydrofuran.
Meschede L, et al.
Berichte der Bunsengesellschaft fur physikalische Chemie, 92(4), 469-485 (1988)
NMR lineshape theory of superimposed intermolecular spin exchange reactions and its action to the system acetic acid/methanol/tetrahydrofuran-d8.
Limbach HH.
Journal of Magnetic Resonance, 36(3), 287-300 (1979)



Global Trade Item Number

SKUGTIN
184314-10G04061837649264
184314-5G04061837613586
184314-5X10G-N04061837649271
184314-10X1G-N04061837613562
184314-1G04061837613579