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195421

10,11-Dihydrocarbamazepine

Name: 10,11-Dihydrocarbamazepine
Brand: ALDRICH

99%

Synonym(s):

10,11-Dihydro-5H-dibenz[b,f]azepine-5-carboxamide

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About This Item

Empirical Formula (Hill Notation):

C₁₅H₁₄N₂O

CAS Number:

3564-73-6

Molecular Weight:

238.28

NACRES:

NA.22

PubChem Substance ID:

24851693

UNSPSC Code:

12352100

EC Number:

222-649-0

MDL number:

MFCD00005072

Assay:

99%

Form:

solid

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Properties

Quality Level

100

assay

99%

form

solid

mp

205-210 °C (lit.)

solubility

dichloromethane: soluble 2.5%, clear, colorless

functional group

amine

SMILES string

NC(=O)N1c2ccccc2CCc3ccccc13

InChI

1S/C15H14N2O/c16-15(18)17-13-7-3-1-5-11(13)9-10-12-6-2-4-8-14(12)17/h1-8H,9-10H2,(H2,16,18)

InChI key

PHNLCHMJDSSPDQ-UHFFFAOYSA-N

Description

General description

10,11-Dihydrocarbamazepine is an impurity present in dibenzazepine drug used in the treatment of epilepsy. Single-crystal structure of new dimer-based polymorph of 10,11-dihydrocarbamazepine has been investigated.

Application

10,11-Dihydrocarbamazepine was used as internal standard during simultaneous determination of carbamazepine and its active metabolite in plasma by liquid chromatography. It was used in chemiluminescence method for determination of carbamazepine.

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pictograms

GHS08,GHS07

signalword

Danger

hcodes

H302,H317,H336,H360D

pcodes

P201 - P280 - P301 + P312 + P330 - P302 + P352 - P308 + P313

Hazard Classifications

Acute Tox. 4 Oral - Repr. 1A - Skin Sens. 1A - STOT SE 3

target_organs

Central nervous system

Storage Class

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

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Determination of carbamazepine by chemiluminescence detection using chemically prepared tris(2,2'-bipyridine)ruthenium(III) as oxidant.

Sang Hak Lee et al.

Analytical sciences : the international journal of the Japan Society for Analytical Chemistry, 19(6), 903-906 (2003-07-02)

A new chemiluminescence method for the determination of carbamazepine (CBZ) has been developed. The method is based on the chemiluminescence produced in the reaction of tris(2,2'-bipyridine)ruthenium(III) and CBZ in an acidic medium. The chemiluminescence intensity was enhanced by organic solvents

A predicted dimer-based polymorph of 10, 11-dihydrocarbamazepine (Form IV).

Arlin J-B, et al.

CrystEngComm, 12(1), 64-66 (2010)

Determination of carbamazepine and its epoxide metabolite in plasma by high-speed liquid chromatography.

M Eichelbaum et al.

Journal of chromatography, 103(1), 135-140 (1975-01-14)

A liquid-chromatographic method for the simultaneous determination of carbamazepine and its active metabolite (carbamazepine 10,11-epoxide) in plasma has been developed. The two compounds were identified in plasma by mass spectrometry. The lower limit of sensitivity is about 4 and 40

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Global Trade Item Number

SKU	GTIN
195421-100MG	04061838761606