257370
7-Amino-4-methylcoumarin
99%
Synonym(s):
Coumarin 120
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About This Item
Empirical Formula (Hill Notation):
C10H9NO2
CAS Number:
Molecular Weight:
175.18
UNSPSC Code:
12352103
NACRES:
NA.23
PubChem Substance ID:
EC Number:
247-454-8
Beilstein/REAXYS Number:
142231
MDL number:
description
chromophore for enzyme substrates
Quality Level
assay
99%
form
solid
mp
223-226 °C (lit.)
λmax
354 nm in ethanol
storage temp.
2-8°C
SMILES string
CC1=CC(=O)Oc2cc(N)ccc12
InChI
1S/C10H9NO2/c1-6-4-10(12)13-9-5-7(11)2-3-8(6)9/h2-5H,11H2,1H3
InChI key
GLNDAGDHSLMOKX-UHFFFAOYSA-N
General description
7-Amino-4-methylcoumarin (coumarin120) is an aminocoumarin laser dye that can emit laser in the range of 370-760 nm. It has three intermolecular hydrogen bonded structures with C-H···O and N-H····O.
Application
Coumarin 120 is used as a fluorescent labeling reagent for trace determination of enzymes. It may be used as an antibacterial agent against MDR isolates of M. tuberculosis as it impacts the cell morphology. Coumarin 120 may also be used as an electron donor (amino groups) to transfer charge in a fluorescent sensor for the detection of mercury ions in aqueous media.
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Storage Class
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
dust mask type N95 (US), Eyeshields, Gloves
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Articles
Graphene is the building block for carbon nanomaterials with different dimensionalities.
Fluorescence quenching microscopy visualizes 2D materials like graphene and MoS2 rapidly, inexpensively, and with high fidelity.
Fluorescence quenching of 7-amino-4-methylcoumarin by different TEMPO derivatives.
Zamojc K, et al.
Spectrochimica Acta. Part A, Molecular and Biomolecular Spectroscopy, 136(12), 1875-1880 (2015)
Aldrichimica Acta, 15, 42-42 (1982)
Sander S van Berkel et al.
ChemMedChem, 7(4), 606-617 (2012-02-02)
The synthesis of a series of peptides containing C-terminal 7-amino-4-methylcoumarin (AMC) for use in the thrombin generation test (TGT) is described. The lead structure in this project was H-Gly-Gly-Arg-AMC, of which the water solubility and kinetic parameters (K(M) and k(cat))
Global Trade Item Number
| SKU | GTIN |
|---|---|
| 257370-500MG | 04061833278994 |
| 257370-100MG | 04061826059357 |