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274313

Phloridzin dihydrate

Name: Phloridzin dihydrate
Brand: ALDRICH

99%

Synonym(s):

1-[2-(β-D-Glucopyranosyloxy)-4,6-dihydroxyphenyl]-3-(4-hydroxyphenyl)-1-propanone, Phloretin 2′-β-D-glucopyranoside, Phloretin 2′-β-D-glucoside, Phlorizin dihydrate

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About This Item

Empirical Formula (Hill Notation):

C₂₁H₂₄O₁₀ · 2H₂O

CAS Number:

7061-54-3

Molecular Weight:

472.44

UNSPSC Code:

12352205

NACRES:

NA.22

PubChem Substance ID:

24856580

EC Number:

200-487-1

Beilstein/REAXYS Number:

66621

MDL number:

MFCD00149438

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Properties

Quality Level

200

assay

99%

form

powder

optical activity

[α]20/D −52°, c = 3 in ethanol

mp

113-114 °C (lit.)

SMILES string

O.O.OC[C@H]1O[C@@H](Oc2cc(O)cc(O)c2C(=O)CCc3ccc(O)cc3)[C@H](O)[C@@H](O)[C@@H]1O

InChI

1S/C21H24O10.2H2O/c22-9-16-18(27)19(28)20(29)21(31-16)30-15-8-12(24)7-14(26)17(15)13(25)6-3-10-1-4-11(23)5-2-10;;/h1-2,4-5,7-8,16,18-24,26-29H,3,6,9H2;2*1H2/t16-,18-,19+,20-,21-;;/m1../s1

InChI key

XQWBNXSENPTIDY-YXMARJSJSA-N

Description

Features and Benefits

Used to induce experimental glycosuria.

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pictograms

GHS07

signalword

Warning

hcodes

H315,H319,H335

pcodes

P261 - P264 - P271 - P280 - P302 + P352 - P305 + P351 + P338

Hazard Classifications

Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

target_organs

Respiratory system

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

dust mask type N95 (US), Eyeshields, Gloves

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No direct effect of SGLT2 activity on glucagon secretion.

Rune E Kuhre et al.

Diabetologia, 62(6), 1011-1023 (2019-03-25)

Sodium-glucose cotransporter (SGLT) 2 inhibitors constitute a new class of glucose-lowering drugs, but they increase glucagon secretion, which may counteract their glucose-lowering effect. Previous studies using static incubation of isolated human islets or the glucagon-secreting cell line α-TC1 suggested that

Proinsulin-producing, hyperglycemia-induced adipose tissue macrophages underlie insulin resistance in high fat-fed diabetic mice.

Eric Dale Buras et al.

FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 29(8), 3537-3548 (2015-05-09)

Adipose tissue macrophages (ATMs) play an important role in the pathogenesis of obese type 2 diabetes. High-fat diet (HFD)-induced obesity has been shown to lead to ATM accumulation in rodents; however, the impact of hyperglycemia on ATM dynamics in HFD-fed

Global Trade Item Number

SKU	GTIN
456373-5G	04061832341385
456373-25G	04061832341378
274313-5G	04061826152546
274313-1G	04061826152522