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299650

2-Phenylquinoline

Name: 2-Phenylquinoline
Brand: ALDRICH

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About This Item

Empirical Formula (Hill Notation):

C₁₅H₁₁N

CAS Number:

612-96-4

Molecular Weight:

205.25

NACRES:

NA.22

PubChem Substance ID:

24858052

UNSPSC Code:

12352100

EC Number:

210-326-7

MDL number:

MFCD00011568

Assay:

99%

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Properties

Quality Level

200

assay

99%

mp

84-85 °C (lit.)

functional group

phenyl

SMILES string

c1ccc(cc1)-c2ccc3ccccc3n2

InChI

1S/C15H11N/c1-2-6-12(7-3-1)15-11-10-13-8-4-5-9-14(13)16-15/h1-11H

InChI key

FSEXLNMNADBYJU-UHFFFAOYSA-N

Gene Information

rat ... Grin2b(24410)

Description

General description

2-Phenylquinoline is the major quinoline alkaloid of Galipea iongiflora, a Bolivian plant used as treatment for cutaneous leishmaniasis. Antinociceptive properties of 2-phenylquinoline isolated from the bark of Galipea iongiflora against different models of pain in mice were evaluated.

Application

2-Phenylquinoline was used in quantitative structure-activity relationship (QSAR) analyses of estrogen receptor β-selective ligands.

pictograms

GHS07

signalword

Warning

hcodes

H315,H319,H335

pcodes

P261 - P264 - P271 - P280 - P302 + P352 - P305 + P351 + P338

Hazard Classifications

Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

target_organs

Respiratory system

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

dust mask type N95 (US), Eyeshields, Gloves

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In vivo efficacy of oral and intralesional administration of 2-substituted quinolines in experimental treatment of new world cutaneous leishmaniasis caused by Leishmania amazonensis.

A Fournet et al.

Antimicrobial agents and chemotherapy, 40(11), 2447-2451 (1996-11-01)

The antileishmanial efficacies of 2-n-propylquinoline, chimanines B and D, 2-n-pentylquinoline, 2-phenylquinoline, 2-(3,4-methylenedioxyphenylethyl) quinoline, and two total alkaloidal extracts of Galipea longiflora were evaluated in BALB/c mice infected with Leishmania amazonensis or Leishmania venezuelensis. Animals were treated for 4 to 6

Descriptor analysis of estrogen receptor β-selective ligands using 2-phenylquinoline, tetrahydrofluorenone and 3-hydroxy 6H-benzo[c]chromen-6-one scaffolds.

Balaji et al.

Journal of enzyme inhibition and medicinal chemistry, 26(6), 831-842 (2011-03-29)

Estrogen receptor beta (ERβ) selective ligands have attracted much attention recently in the design of anti-cancer drugs that are devoid of the common side effects of estrogen. Structural studies of estrogen receptor alpha (ERα) and β revealed that there were

Evaluation of antinociceptive effects of Galipea longiflora alkaloid extract and major alkaloid 2-phenylquinoline.

F Campos-Buzzi et al.

Methods and findings in experimental and clinical pharmacology, 32(10), 707-711 (2011-01-13)

The present study evaluated the antinociceptive properties of an alkaloid extract and 2-phenylquinoline obtained from the bark of Galipea longiflora Krause (Rutaceae) against different models of pain in mice. The results demonstrate that the alkaloid extract caused a pronounced antinociceptive

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Global Trade Item Number

SKU	GTIN
299650-1G	04061826257760
299650-5G	04061833546352