Key Documents

View All Documentation

302309

2-Cyanoethyl N,N-diisopropylchlorophosphoramidite

Name: 2-Cyanoethyl <I>N,N</I>-diisopropylchlorophosphoramidite
Brand: ALDRICH

Cl 13.5-15.5 %

Synonym(s):

Chloro(diisopropylamino)-β-cyanoethoxyphosphine

Select a Size

Change View

About This Item

Linear Formula:

[(CH₃)₂CH]₂NP(Cl)OCH₂CH₂CN

CAS Number:

89992-70-1

Molecular Weight:

236.68

UNSPSC Code:

12352100

NACRES:

NA.22

PubChem Substance ID:

24858245

MDL number:

MFCD00011544

Beilstein/REAXYS Number:

3588525

Form:

liquid

Technical Service

Need help? Our team of experienced scientists is here for you.

Let Us Assist

Properties

form

liquid

Quality Level

200

composition

Cl, 13.5-15.5%

refractive index

n/D 1.476-1.480

bp

103 -105 °C/0.1 hPa

density

1.061 g/mL at 25 °C (lit.)

functional group

amine, nitrile

storage temp.

−20°C

SMILES string

CC(C)N(C(C)C)P(Cl)OCCC#N

InChI

1S/C9H18ClN2OP/c1-8(2)12(9(3)4)14(10)13-7-5-6-11/h8-9H,5,7H2,1-4H3

InChI key

QWTBDIBOOIAZEF-UHFFFAOYSA-N

Description

Application

2-Cyanoethyl N,N-diisopropylchlorophosphoramidite was employed:

for selective monophosphorylation of carbohydrates and nucleosides
for conversion of protected ribonucleosides to phosphoramidites
as phosphitylating reagent for 3′-hydroxyl groups in the synthesis of oligodeoxyribonucleotides
in a scalable, solution-phase oligonucleotide synthesis employing phosphoramidite chemistry and DMT-, iBu- and Bz-protected monomers. Intermediates were isolated by extraction without further purification

Still not finding the right product?

Explore all of our products under 2-Cyanoethyl N,N-diisopropylchlorophosphoramidite

pictograms

GHS02,GHS05

signalword

Danger

hcodes

H250,H314

pcodes

P210 - P231 + P232 - P280 - P303 + P361 + P353 - P305 + P351 + P338 - P370 + P378

Hazard Classifications

Eye Dam. 1 - Pyr. Liq. 1 - Skin Corr. 1B

Storage Class

4.2 - Pyrophoric and self-heating hazardous materials

wgk

WGK 3

flash_point_f

230.0 °F - closed cup

flash_point_c

110 °C - closed cup

ppe

Faceshields, Gloves, Goggles, type ABEK (EN14387) respirator filter

Regulatory Information

新产品

This item has

Choose from one of the most recent versions:

Certificates of Analysis (COA)

Lot/Batch Number

Don't see the Right Version?

If you require a particular version, you can look up a specific certificate by the Lot or Batch number.

Search for a COA

Already Own This Product?

Find documentation for the products that you have recently purchased in the Document Library.

Visit the Document Library

Organic Process Research & Development, 10, 1238-1238 (2006)

Nucleosides and nucleotides. 121. Synthesis of oligonucleotides carrying linker groups at the 1'-position of sugar residues.

A Ono et al.

Bioconjugate chemistry, 4(6), 499-508 (1993-11-01)

Novel 2'-deoxyuridine analogues carrying aminoalkyl linkers at the 1'-position of the sugar residues were synthesized and incorporated into oligonucleotides, then intercalating groups such as an anthraquinone derivative and a pyrene derivative were attached to the amino groups. Duplexes consisting of

Tetrahedron Letters, 45, 509-509 (2004)

View All Related Papers

Global Trade Item Number

SKU	GTIN
302309-250MG	04061837656385
302309-1G	04061837656378
302309-5G	04061826665831