345571
1,5,7-Triazabicyclo[4.4.0]dec-5-ene
98%
Synonym(s):
1,3,4,6,7,8-Hexahydro-2H-pyrimido[1,2-a]pyrimidine, Hhpp, TBD
Sign In to View Organizational & Contract Pricing.
Select a Size
Change View
About This Item
Empirical Formula (Hill Notation):
C7H13N3
CAS Number:
Molecular Weight:
139.20
UNSPSC Code:
12352100
NACRES:
NA.22
PubChem Substance ID:
EC Number:
227-367-1
Beilstein/REAXYS Number:
3242
MDL number:
Assay:
98%
Form:
crystals
Quality Level
assay
98%
form
crystals
mp
125-130 °C (lit.)
solubility
acetonitrile: soluble, ethanol: soluble, organic solvents: soluble, water: soluble
SMILES string
C1CNC2=NCCCN2C1
InChI
1S/C7H13N3/c1-3-8-7-9-4-2-6-10(7)5-1/h1-6H2,(H,8,9)
InChI key
FVKFHMNJTHKMRX-UHFFFAOYSA-N
General description
1,5,7-Triazabicyclo[4.4.0]dec-5-ene, a bicyclic guanidine base, has been found to be an excellent catalyst for Michael and Michael-type reactions. It forms 1:1 complex with lasalocid acid and crystal structure of the complex has been studied by X-ray diffraction, FT-IR spectroscopy and 1H NMR.
Application
1,5,7-Triazabicyclo[4.4.0]dec-5-ene may be used as organocatalyst for aminolysis of esters. It may be used as catalyst for direct addition of P(O)-H bonds (dialkyl phosphites and diphenyl phosphonite) across various activated alkenes. Polymer supported 1,5,7-triazabicyclo[4.4.0]dec-5-ene (PTBD) was used as a base and a reagent scavenger for the synthesis of aryl ethers from phenols and alkyl or aryl halides.
signalword
Danger
Storage Class
8A - Combustible corrosive hazardous materials
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Faceshields, Gloves, type P3 (EN 143) respirator cartridges
hcodes
Hazard Classifications
Acute Tox. 4 Oral - Aquatic Chronic 3 - Eye Dam. 1 - Skin Corr. 1A
Choose from one of the most recent versions:
Already Own This Product?
Find documentation for the products that you have recently purchased in the Document Library.
Jinfeng Wang et al.
Journal of surgical oncology, 111(8), 992-999 (2015-05-16)
We aimed to investigate potential of urinary cell-free microRNA-214 (miR-214) as a noninvasive biomarker for bladder cancer in this report. We screened miR-214 expression in medium from 2 bladder cancer cell lines to determine whether it is secretory. Then we
1, 5, 7-Triazabicyclo [4.4. 0] dec-5-ene (TBD) catalyzed Michael reactions.
Ye W, et al.
Tetrahedron Letters, 46(40), 6875-6878 (2005)
A convenient aminolysis of esters catalyzed by 1, 5, 7-triazabicyclo [4.4. 0] dec-5-ene (TBD) under solvent-free conditions.
Sabot C, et al.
Tetrahedron Letters, 48(22), 3863-3866 (2007)
Global Trade Item Number
| SKU | GTIN |
|---|---|
| 345571-5G | 04061826760789 |