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361518

1-Hydroxypyrene

Name: 1-Hydroxypyrene
Brand: ALDRICH

98%

Synonym(s):

1-Pyrenol

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About This Item

Empirical Formula (Hill Notation):

C₁₆H₁₀O

CAS Number:

5315-79-7

Molecular Weight:

218.25

NACRES:

NA.22

PubChem Substance ID:

24862229

UNSPSC Code:

12352100

MDL number:

MFCD00044543

Assay:

98%

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Properties

Quality Level

100

assay

98%

mp

179-182 °C (lit.)

SMILES string

Oc1ccc2ccc3cccc4ccc1c2c34

InChI

1S/C16H10O/c17-14-9-7-12-5-4-10-2-1-3-11-6-8-13(14)16(12)15(10)11/h1-9,17H

InChI key

BIJNHUAPTJVVNQ-UHFFFAOYSA-N

Description

General description

1-Hydroxypyrene, as a urinary metabolite, is a marker of polycyclic aromatic hydrocarbons (PAH) exposure. 1-Hydroxypyrene is an important biomarker of exposure to pyrene.

Application

1-Hydroxypyrene is suitable for use in following studies:

To investigate the fast detection and quantification of 1-hydroxypyrene in tissue extracts from Nereis diversicolor exposed to sediment-associated pyrene by a simple fluorometric method.
To investigate the effects of genetic polymorphisms of the cytochrome P450 1A1 (CYP1A1) and 2E1 (CYP2E1) and glutathione S-transferases mu (GSTM1) and theta (GSTT1) on urinary 1-hydroxypyrene and 2-naphthol levels in aircraft maintenance workers.
To examine the the PAH exposure of cokery workers in an Estonian oil shale processing plant.

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Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

dust mask type N95 (US), Eyeshields, Gloves

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Synchronous fluorescence spectrometry of 1-hydroxypyrene: a rapid screening method for identification of PAH exposure in tissue from marine polychaetes.

Anders M B Giessing et al.

Marine environmental research, 56(5), 599-615 (2003-08-21)

The uptake of polycyclic aromatic hydrocarbons (PAHs) by marine deposit-feeding invertebrates can be determined by screening for PAH-derived metabolites. We identified 1-hydroxypyrene as the only intermediate metabolite in tissue of four species of deposit-feeding polychaetes, Nereis diversicolor, Nereis virens, Arenicola

Exposure to chemical mixtures in Mexican children: high-risk scenarios.

Gabriela Domínguez-Cortinas et al.

Environmental science and pollution research international, 20(1), 351-357 (2012-05-01)

In developing countries, the management of environmental toxicants is inadequate, thus, humans may be exposed to levels higher than normal levels (background levels). Therefore, the aim of this study was to evaluate the exposure level of Mexican children to dichlorodiphenyltrichloroethane

ETS Exposure and PAH Body Burden in Nonsmoking Italian Adults.

Laura Campo et al.

International journal of environmental research and public health, 15(6) (2018-06-06)

Active smoking is associated with increased body burden of polycyclic aromatic hydrocarbons (PAHs); the aim of this study was to assess whether environmental tobacco smoking (ETS) increases the internal dose of PAHs. In 344 nonsmoking Italian adults, out of 497

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Global Trade Item Number

SKU	GTIN
361518-100MG	04061831824278
361518-500MG	04061831824285