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402516

1H-Pyrazole-1-carboxamidine hydrochloride

Name: 1<I>H</I>-Pyrazole-1-carboxamidine hydrochloride
Brand: ALDRICH

99%

Synonym(s):

1-Amidinopyrazole hydrochloride, Praxadine

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About This Item

Empirical Formula (Hill Notation):

C₄H₆N₄ · HCl

CAS Number:

4023-02-3

Molecular Weight:

146.58

UNSPSC Code:

12352100

NACRES:

NA.22

PubChem Substance ID:

24865095

EC Number:

429-520-1

Beilstein/REAXYS Number:

5448758

MDL number:

MFCD00210087

Assay:

99%

Form:

powder

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Properties

Quality Level

200

assay

99%

form

powder

mp

167-170 °C (lit.)

functional group

amine

SMILES string

Cl[H].NC(=N)n1cccn1

InChI

1S/C4H6N4.ClH/c5-4(6)8-3-1-2-7-8;/h1-3H,(H3,5,6);1H

InChI key

RBZRMBCLZMEYEH-UHFFFAOYSA-N

Description

General description

1H-Pyrazole-1-carboxamidine hydrochloride, a pyrazole derivative, is a heterocyclic compound. It is widely used in drug syntheses studies. Pyrazole ring forms the main core of various nonsteroidal anti-inflammatory drugs (NSAIDs) and antihypertensive drugs.

Application

1H-Pyrazole-1-carboxamidine hydrochloride may be used in the following studies:

Preparation of guanidylated hollow fiber membranes.
Guanylation of amines and in peptide synthesis.
Synthesis of bis-guanidinium-cholesterol derivatives.

pictograms

GHS08,GHS05,GHS07

signalword

Danger

hcodes

H302,H317,H318,H373,H412

pcodes

P273 - P280 - P301 + P312 - P302 + P352 - P305 + P351 + P338 - P314

Hazard Classifications

Acute Tox. 4 Oral - Aquatic Chronic 3 - Eye Dam. 1 - Skin Sens. 1 - STOT RE 2

Storage Class

11 - Combustible Solids

wgk

WGK 2

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

dust mask type N95 (US), Eyeshields, Gloves

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Guanidinylation of Chitooligosaccharides Involving Internal Cyclization of the Guanidino Group on the Reducing End and Effect of Guanidinylation on Protein Binding Ability.

Hironori Izawa et al.

Biomolecules, 9(7) (2019-07-10)

In order to synthesize a promising material for developing a novel peptide/protein delivery system, guanidinylation of chitooligosaccharides with 1-amidinopyrazole hydrochloride was investigated herein. The production of guanidinylated chitooligosaccharides was demonstrated by infrared spectroscopy (IR), nuclear magnetic resonance (NMR), and elemental

1H-Pyrazole-1-carboxamidine hydrochloride an attractive reagent for guanylation of amines and its application to peptide synthesis.

Bernatowicz MS, et al.

The Journal of Organic Chemistry, 57(8), 2497-2502 (1992)

Guanidinium-cholesterol cationic lipids: efficient vectors for the transfection of eukaryotic cells.

J P Vigneron et al.

Proceedings of the National Academy of Sciences of the United States of America, 93(18), 9682-9686 (1996-09-03)

Two cationic lipids, bis-guanidinium-spermidine-cholesterol (BGSC) and bis-guanidinium-trencholesterol (BGTC)-cholesterol derivatives bearing two guanidinium groups-have been synthesized and tested as artificial vectors for gene transfer. They combine the membrane compatible features of the cholesterol subunit and the favorable structural and high pKa

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Global Trade Item Number

SKU	GTIN
402516-10G	04061832993638
402516-50G	04061831985900