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404861

Tetrakis(hydroxymethyl)phosphonium chloride solution

Name: Tetrakis(hydroxymethyl)phosphonium chloride solution
Brand: ALDRICH

80% in H2O, liquid

Synonym(s):

THPC solution

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About This Item

Linear Formula:

(HOCH₂)₄PCl

CAS Number:

124-64-1

Molecular Weight:

190.56

NACRES:

NA.22

PubChem Substance ID:

24865276

UNSPSC Code:

12352101

MDL number:

MFCD00031687

Beilstein/REAXYS Number:

3631669

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Properties

Product Name

Tetrakis(hydroxymethyl)phosphonium chloride solution, 80% in H₂O

assay

79.1%

form

liquid

reaction suitability

core: phosphonium

concentration

80% in H₂O

refractive index

n20/D 1.512

density

1.341 g/mL at 25 °C

SMILES string

[Cl-].OC[P+](CO)(CO)CO

InChI

1S/C4H12O4P.ClH/c5-1-9(2-6,3-7)4-8;/h5-8H,1-4H2;1H/q+1;/p-1

InChI key

AKXUUJCMWZFYMV-UHFFFAOYSA-M

Description

Application

Tetrakis(hydroxymethyl)phosphonium chloride solution (80% in H₂O) has been used as a reducing agent and stabilizing ligand for the synthesis of gold nanoparticles (AuNPs) from gold(III) chloride trihydrate (HAuCl₄.3H₂O). It is a tetra-functional, amine-reactive, aqueous crosslinker that can be used for tuning the properties of protein-based hydrogels for 3D cell encapsulation applications.

pictograms

GHS06,GHS08,GHS05,GHS09

signalword

Danger

hcodes

H290,H301 + H311,H314,H317,H360FD,H410

pcodes

P201 - P273 - P280 - P303 + P361 + P353 - P304 + P340 + P310 - P305 + P351 + P338

Hazard Classifications

Acute Tox. 3 Dermal - Acute Tox. 3 Oral - Aquatic Acute 1 - Aquatic Chronic 1 - Eye Dam. 1 - Met. Corr. 1 - Repr. 1B - Skin Corr. 1B - Skin Sens. 1

Storage Class

6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Faceshields, Gloves, type ABEK (EN14387) respirator filter

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Beyond gold: rediscovering tetrakis-(hydroxymethyl)-phosphonium chloride (THPC) as an effective agent for the synthesis of ultra-small noble metal nanoparticles and Pt-containing nanoalloys

Hueso J L, et al.

Royal Society of Chemistry Advances, 3(26), 10427-10433 (2013)

Facile preparation of water-soluble fluorescent gold nanoclusters for cellular imaging applications.

Shang L, et al.

Nanoscale, 3(5), 2009-2014 (2011)

The characterisation of three substituted zinc phthalocyanines of differing charge for use in photodynamic therapy. A comparative study of their aggregation and photosensitising ability in relation to mTHPC and polyhaematoporphyrin.

D J Ball et al.

Journal of photochemistry and photobiology. B, Biology, 45(1), 28-35 (1998-11-20)

Three substituted zinc (II) phthalocyanines (one anionic, one cationic and one hydrophobic) have been compared to two clinically used photosensitisers, 5,10,15,20-tetra (m-hydroxyphenyl) chlorin (mTHPC) and polyhaematoporphyrin (PHP), as potential agents for photodynamic therapy (PDT). Oxygen-consumption experiments, performed to follow the

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Global Trade Item Number

SKU	GTIN
404861-100ML	04061831987027
404861-500ML	04061831987041