41996
1-Hydroxy-7-azabenzotriazole solution
~0.6 M in DMF, for peptide synthesis
Synonym(s):
3H-[1,2,3]-Triazolo[4,5-b]pyridin-3-ol, HOAt
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About This Item
Empirical Formula (Hill Notation):
C5H4N4O
CAS Number:
Molecular Weight:
136.11
NACRES:
NA.22
PubChem Substance ID:
UNSPSC Code:
12352005
MDL number:
Beilstein/REAXYS Number:
1211115
Product Name
1-Hydroxy-7-azabenzotriazole solution, ~0.6 M in DMF
form
liquid
Quality Level
reaction suitability
reaction type: Addition Reactions
concentration
~0.6 M in DMF
impurities
<1.0% water
refractive index
n20/D 1.441
density
0.978 g/mL at 20 °C
application(s)
peptide synthesis
SMILES string
On1nnc2cccnc12
InChI
1S/C5H4N4O/c10-9-5-4(7-8-9)2-1-3-6-5/h1-3,10H
InChI key
FPIRBHDGWMWJEP-UHFFFAOYSA-N
General description
1-Hydroxy-7-azabenzotriazole solution, also known as 3H-[1,2,3]-triazolo[4,5-b]pyridin-3-ol, is a benzotriazolic additive that is commonly used as a coupling reagent for amino acids and peptides. It is also used to minimize epimerization.
Application
1-Hydroxy-7-azabenzotriazole solution is used as a reagent in the solid-phase synthesis of chiral peptide nucleic acids.
Other Notes
Coupling additive for efficient racemization-free coupling in peptide synthesis; segment coupling.
signalword
Danger
Hazard Classifications
Acute Tox. 4 Dermal - Acute Tox. 4 Inhalation - Eye Irrit. 2 - Flam. Liq. 3 - Repr. 1B
Storage Class
3 - Flammable liquids
flash_point_f
136.4 °F - closed cup
flash_point_c
58 °C - closed cup
ppe
Eyeshields, Faceshields, Gloves, type ABEK (EN14387) respirator filter
Regulatory Information
危险化学品
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L.A. Carpino, A. El-Faham
Tetrahedron, 55, 6813-6813 (1999)
Hsuan-Ni Lin et al.
Journal of orthopaedic research : official publication of the Orthopaedic Research Society, 34(11), 1883-1893 (2016-02-27)
Fracture healing is regulated by a variety of inflammatory mediators and growth factors which act over time to regenerate the injured tissue. This study used a mouse femur fracture model to quantify the temporal expression pattern of lipid mediators, cytokines
Y. Nishiyama et al.
Tetrahedron Letters, 42, 8789-8789 (2001)
Global Trade Item Number
| SKU | GTIN |
|---|---|
| 41996-25ML-F | 04061838119759 |
| 41996-100ML-F | 04061838119742 |