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47622

Fmoc-Thr(tBu)-OH

Name: Fmoc-Thr(tBu)-OH
Brand: ALDRICH

≥98.0% (HPLC), for peptide synthesis

Synonym(s):

Fmoc-O-tert-butyl-L-threonine

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About This Item

Empirical Formula (Hill Notation):

C₂₃H₂₇NO₅

CAS Number:

71989-35-0

Molecular Weight:

397.46

NACRES:

NA.26

PubChem Substance ID:

57651042

eCl@ss:

32160406

UNSPSC Code:

12352209

EC Number:

276-261-1

MDL number:

MFCD00077075

Beilstein/REAXYS Number:

4581133

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Properties

Product Name

Fmoc-Thr(tBu)-OH, ≥98.0% (HPLC)

Quality Level

100

assay

≥98.0% (HPLC)

optical activity

[α]20/D +16±1°, c = 1% in ethyl acetate

reaction suitability

reaction type: C-H Activation, reaction type: Fmoc solid-phase peptide synthesis, reagent type: ligand
reaction type: Peptide Synthesis

application(s)

peptide synthesis

functional group

Fmoc, amine, carboxylic acid

storage temp.

2-8°C

SMILES string

C[C@@H](OC(C)(C)C)[C@H](NC(=O)OCC1c2ccccc2-c3ccccc13)C(O)=O

InChI

1S/C23H27NO5/c1-14(29-23(2,3)4)20(21(25)26)24-22(27)28-13-19-17-11-7-5-9-15(17)16-10-6-8-12-18(16)19/h5-12,14,19-20H,13H2,1-4H3,(H,24,27)(H,25,26)/t14-,20+/m1/s1

InChI key

LZOLWEQBVPVDPR-VLIAUNLRSA-N

Description

General description

Fmoc-Thr(tBu)-OH also known as Fmoc-O-tert-butyl-L-threonine, is commonly used as amino acid building block in peptide synthesis.

Application

Fmoc-Thr(tBu)-OH can be used to synthesize chlorofusin analogues via solid phase peptide synthesis. Additionally, it can serve as a protecting group for both the amine and the hydroxyl functions in solid-phase synthesis of complex depsipeptides.

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Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

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Antibody Epitope of Human α-Galactosidase A Revealed by Affinity Mass Spectrometry: A Basis for Reversing Immunoreactivity in Enzyme Replacement Therapy of Fabry Disease.

Zdenek Kukacka et al.

ChemMedChem, 13(9), 909-915 (2018-02-24)

α-Galactosidase (αGal) is a lysosomal enzyme that hydrolyses the terminal α-galactosyl moiety from glycosphingolipids. Mutations in the encoding genes for αGal lead to defective or misfolded enzyme, which results in substrate accumulation and subsequent organ dysfunction. The metabolic disease caused

Substitution determination of Fmoc-substituted resins at different wavelengths.

Stefan Eissler et al.

Journal of peptide science : an official publication of the European Peptide Society, 23(10), 757-762 (2017-06-22)

In solid-phase peptide synthesis, the nominal batch size is calculated using the starting resin substitution and the mass of the starting resin. The starting resin substitution constitutes the basis for the calculation of a whole set of important process parameters

Global Trade Item Number

SKU	GTIN
47622-1KG-F	04061826222676
47622-100G-F	04061832362168
47622-10G-F	04061832362175
47622-1G-F	04061826222669
47622-25G-F	04061832642550