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Merck
CN

47636

Fmoc-Pro-OH

≥90% (HPLC)

Synonym(s):

N-(9-Fluorenylmethoxycarbonyl)-L-proline, Fmoc-L-proline

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About This Item

Empirical Formula (Hill Notation):
C20H19NO4
CAS Number:
Molecular Weight:
337.37
NACRES:
NA.26
PubChem Substance ID:
eCl@ss:
32160406
UNSPSC Code:
12352209
EC Number:
276-259-0
MDL number:
Beilstein/REAXYS Number:
3596735
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Quality Level

assay

≥90% (HPLC)

optical activity

[α]20/D −32±1°, c = 1% in DMF

reaction suitability

reaction type: Fmoc solid-phase peptide synthesis

mp

117-118 °C (lit.)

application(s)

peptide synthesis

functional group

Fmoc

storage temp.

2-8°C

SMILES string

OC(=O)[C@@H]1CCCN1C(=O)OCC2c3ccccc3-c4ccccc24

InChI

1S/C20H19NO4/c22-19(23)18-10-5-11-21(18)20(24)25-12-17-15-8-3-1-6-13(15)14-7-2-4-9-16(14)17/h1-4,6-9,17-18H,5,10-12H2,(H,22,23)/t18-/m0/s1

InChI key

ZPGDWQNBZYOZTI-SFHVURJKSA-N



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Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)



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Articles

Proline analogues are promising candidates for tuning the biological, pharmaceutical, or physicochemical properties of naturally occuring, as well as de novo designed, linear, and, cyclic peptides.


Magdalena Rudowska et al.
Journal of the American Society for Mass Spectrometry, 24(6), 846-856 (2013-04-24)
The fragmentation of peptides containing quaternary ammonium group, but lacking easily mobilizable protons, was examined with the aid of deuterium-labeled analogs and quantum-chemical modeling. The fragmentation of oligoproline containing quaternary ammonium group involves the mobilization of hydrogens localized at α-
Rosanna Capparelli et al.
PloS one, 4(9), e7191-e7191 (2009-09-29)
Temporins are antimicrobial peptides secreted by the granular glands of the European red frog (Rana temporaria). They are 10-14 amino acid long polypeptides active prevalently against gram positive bacteria. This study shows that a synthetic temporin B analogue (TB-YK), acquires
Karthik Nadendla et al.
Molecular pharmaceutics, 16(7), 2922-2928 (2019-05-24)
We have previously described the photoactivated depot (PAD) approach for the light-stimulated release of therapeutic proteins such as insulin. The aim of this method is to release insulin from a shallow dermal depot in response to blood glucose information, using



Global Trade Item Number

SKUGTIN
47636-5G-F04061832362441
47636-1KG-F04061826222768
47636-250G-F04061832362403
47636-50G-F04061832362427