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48640

Ethyl gallate

Name: Ethyl gallate
Brand: ALDRICH

antioxidant, ≥96.0% (HPLC)

Synonym(s):

3,4,5-Trihydroxybenzoic acid ethyl ester, Ethyl 3,4,5-trihydroxybenzoate, Progallin A

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About This Item

Linear Formula:

3,4,5-(OH)₃C₆H₂COOC₂H₅

CAS Number:

831-61-8

Molecular Weight:

198.17

UNSPSC Code:

12352100

NACRES:

NA.22

PubChem Substance ID:

57651155

EC Number:

212-608-5

Beilstein/REAXYS Number:

2116014

MDL number:

MFCD00016430

Assay:

≥96.0% (HPLC)

Form:

solid

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Properties

Quality Level

100

assay

≥96.0% (HPLC)

form

solid

functional group

ester

SMILES string

CCOC(=O)c1cc(O)c(O)c(O)c1

InChI

1S/C9H10O5/c1-2-14-9(13)5-3-6(10)8(12)7(11)4-5/h3-4,10-12H,2H2,1H3

InChI key

VFPFQHQNJCMNBZ-UHFFFAOYSA-N

Description

General description

Ethyl gallate is the ethyl ester of gallic acid that belongs to a class of phenolic compound. It is an aromatic compound that is commonly used as a starting material during the synthesis of ellagic acid via transesterification reactions.

Application

Ethyl gallate is utilized as a reactant in thesynthesis of quinoxalines via sustainable green chemistry process.

Wound healing enhancement: Ethyl gallate, isolated from Caesalpinia mimosoides, demonstrated significant effects in promoting cutaneous wound healing. This discovery supports its potential application in therapeutic treatments for skin regeneration (Bhat et al., 2023).
Pharmacokinetics in ethanolic extracts: A study involving ethanolic extracts of Terminalia chebula, which include ethyl gallate, detailed the pharmacokinetics of these active compounds in rats, providing critical data for pharmaceutical applications and drug development processes (Yao et al., 2023).
Ethnopharmacology research: Research on Rubus idaeus, a source of ethyl gallate, covered extensive ethnobotany, phytochemical, and pharmacological aspects, offering insights into traditional uses and modern applications, highlighting its potential in ethnopharmacology (Tao et al., 2023).
Dermal applications: Ethyl gallate was used in a topical ointment from Caesalpinia mimosoides to attenuate dermal wounds. This application underscores its effectiveness in skin care and treatment strategies (Bhat et al., 2022).
Neuroprotective effects: The Jingchuan tablet, which includes ethyl gallate, has been studied for its therapeutic role in treating ischaemic cerebral stroke, focusing on the HIF-1α/EPO/VEGFA signalling pathway. This research outlines its importance in neuroprotective strategies (Zhang et al., 2022).

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Storage Class

11 - Combustible Solids

wgk

WGK 2

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

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Protocols

HPLC Analysis of Polyphenols in Nero d'Avola Red Wine on Discovery® HS C18 (UV 280 nm)

Thermodynamic and computational analyses reveal the functional roles of the galloyl group of tea catechins in molecular recognition.

Tomoya Takahashi et al.

PloS one, 13(10), e0204856-e0204856 (2018-10-12)

Catechins, biologically active polyphenols in green tea, exhibit various biological activities, such as anticancer and antiviral activities, arising from interactions with functional proteins. However, the molecular details of these interactions remain unclear. In this study, we investigated the interactions between

Rhodiola crenulata attenuates apoptosis and mitochondrial energy metabolism disorder in rats with hypobaric hypoxia-induced brain injury by regulating the HIF-1α/microRNA 210/ISCU1/2(COX10) signaling pathway.

Xiaobo Wang et al.

Journal of ethnopharmacology, 241, 111801-111801 (2019-03-18)

Rhodiola crenulata, a traditional Tibetan medicine, has shown promise in the treatment of hypobaric hypoxia (HH)-induced brain injury. However, the underlying mechanisms remain unclear. This study investigated the protective effects of R. crenulata aqueous extract (RCAE) on HH-induced brain injury

Ethyl gallate, a scavenger of hydrogen peroxide that inhibits lysozyme-induced hydrogen peroxide signaling in vitro, reverses hypotension in canine septic shock.

Steven N Mink et al.

Journal of applied physiology (Bethesda, Md. : 1985), 110(2), 359-374 (2010-11-13)

Although hydrogen peroxide (H2O2) is a well-described reactive oxygen species that is known for its cytotoxic effects and associated tissue injury, H2O2 has recently been established as an important signaling molecule. We previously demonstrated that lysozyme (Lzm-S), a mediator of

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Global Trade Item Number

SKU	GTIN
48640-500G-F	04061832491776
48640-100G-F	04061832392523