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558958

4-Chlorobenzyl bromide

97%

Synonym(s):

α-Bromo-p-chlorotoluene, 1-(Bromomethyl)-4-chlorobenzene, 1-Chloro-4-bromomethylbenzene, p-Chlorobenzyl bromide

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About This Item

Linear Formula:
ClC6H4CH2Br
CAS Number:
622-95-7
Molecular Weight:
205.48
NACRES:
NA.22
PubChem Substance ID:
24879785
UNSPSC Code:
12352100
EC Number:
210-760-7
MDL number:
MFCD00040714
Assay:
97%
Form:
solid
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Quality Level

200

assay

97%

form

solid

mp

48-52 °C (lit.)

functional group

bromo, chloro

SMILES string

Clc1ccc(CBr)cc1

InChI

1S/C7H6BrCl/c8-5-6-1-3-7(9)4-2-6/h1-4H,5H2

InChI key

KQNBRMUBPRGXSL-UHFFFAOYSA-N

General description

4-Chlorobenzyl bromide undergoes carbonylation in the presence of dimer of chloro(1,5-cyclooctadiene)rhodium(I) to yield the corresponding phenylacetic acid. It can be synthesized by reacting 4-chlorobenzyl alcohol with bromodimethylsulfonium bromide (BDMS) It can also be synthesized by refluxing a mixture of 4-chlorobenzaldehyde, chlorotrimethylsilane, 1,1,3,3-tetramethyldisiloxane and lithium bromide.

Application

4-Chlorobenzyl bromide may be used to synthesize:

  • 1-(4-chlorobenzyl)-2-(pyrrolidin-1-yl-methyl)-1H-benzimidazole dihydrochloride
  • 1-[1-[2-[(4-chlorobenzyl)thio]phenyl]vinyl]-1H-imidazole
  • 6-[4-(4-chlorobenzyl)piperazinyl]chromane
  • N,N′-bis(4-chlorobenzyl)piperazine
  • N-(4-chlorobenzyl)piperazine

pictograms

Corrosion
GHS05

signalword

Danger

hcodes

H314

Hazard Classifications

Skin Corr. 1B

Storage Class

8A - Combustible corrosive hazardous materials

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Faceshields, Gloves, type P3 (EN 143) respirator cartridges

Regulatory Information

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Certificates of Analysis (COA)

Lot/Batch Number
BCCC8006
BCBT0398
BCBT3774
BCBM4560V
BCBJ2727V

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Global Trade Item Number

SKUGTIN
558958-25G04061833548417
558958-100G04061833548400