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61250

DL-Kynurenine

Name: <SC>DL</SC>-Kynurenine
Brand: ALDRICH

≥95.0% (NT), for peptide synthesis

Synonym(s):

2-Amino-3-(2-aminobenzoyl)propionic acid, 2-Amino-4-(2-aminophenyl)-4-oxobutyric acid

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About This Item

Empirical Formula (Hill Notation):

C₁₀H₁₂N₂O₃

CAS Number:

343-65-7

Molecular Weight:

208.21

NACRES:

NA.22

PubChem Substance ID:

57651839

UNSPSC Code:

12352209

EC Number:

206-445-9

MDL number:

MFCD00025194

Beilstein/REAXYS Number:

2697333

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Properties

Product Name

DL-Kynurenine, ≥95.0% (NT)

Quality Level

100

assay

≥95.0% (NT)

form

powder

mp

~235 °C (dec.)

application(s)

peptide synthesis

SMILES string

NC(CC(=O)c1ccccc1N)C(O)=O

InChI

1S/C10H12N2O3/c11-7-4-2-1-3-6(7)9(13)5-8(12)10(14)15/h1-4,8H,5,11-12H2,(H,14,15)

InChI key

YGPSJZOEDVAXAB-UHFFFAOYSA-N

Description

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Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

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Serum metabolite profiles of postoperative fatigue syndrome in rat following partial hepatectomy.

Ye Lu et al.

Journal of clinical biochemistry and nutrition, 58(3), 210-215 (2016-06-04)

Postoperative fatigue syndrome is a general complication after surgery. However, there is no ''gold standard'' for fatigue assessment due to the lack of objective biomarkers. In this study, a rodent model of postoperative fatigue syndrome based on partial hepatectomy was

Leucine competes with kynurenine for blood-to-brain transport and prevents lipopolysaccharide-induced depression-like behavior in mice.

Adam K Walker et al.

Molecular psychiatry, 24(10), 1523-1532 (2018-07-11)

Inflammation activates indoleamine 2,3-dioxygenase (IDO) which metabolizes tryptophan into kynurenine. Circulating kynurenine is transported into the brain by the large amino transporter LAT1 at the level of the blood-brain barrier. We hypothesized that administration of leucine that has a high

Kynurenines in the CNS: recent advances and new questions.

László Vécsei et al.

Nature reviews. Drug discovery, 12(1), 64-82 (2012-12-15)

Various pathologies of the central nervous system (CNS) are accompanied by alterations in tryptophan metabolism. The main metabolic route of tryptophan degradation is the kynurenine pathway; its metabolites are responsible for a broad spectrum of effects, including the endogenous regulation

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Global Trade Item Number

SKU	GTIN
61250-1G	04061826095416
61250-250MG	04061832595276