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900584

5-Ethynyl-2′-deoxyuridine

Name: 5-Ethynyl-2′-deoxyuridine
Brand: ALDRICH

95%

Synonym(s):

EdU

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About This Item

Empirical Formula (Hill Notation):

C₁₁H₁₂N₂O₅

CAS Number:

61135-33-9

Molecular Weight:

252.22

MDL number:

MFCD01675687

UNSPSC Code:

12352208

NACRES:

NA.22

Assay:

95%

Form:

powder

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Properties

Quality Level

100

assay

95%

form

powder

manufacturer/tradename

(BCN-001)

mp

206 °C

storage temp.

−20°C

SMILES string

OC[C@@H]1[C@@H](O)C[C@H](N2C(NC(C(C#C)=C2)=O)=O)O1

InChI

1S/C11H12N2O5/c1-2-6-4-13(11(17)12-10(6)16)9-3-7(15)8(5-14)18-9/h1,4,7-9,14-15H,3,5H2,(H,12,16,17)/t7-,8+,9+/m0/s1

InChI key

CDEURGJCGCHYFH-DJLDLDEBSA-N

Description

General description

5-Ethynyl-2′-deoxyuridine (EdU) is a thymidine analogue that can be incorporated into cellular DNA for cell proliferation studies. The incorporated nucleoside analogue can be detected by a copper-catalyzed click reaction with a fluorescent azide.

Application

5-Ethynyl-2′-deoxyuridine (EdU) is used for:

Labeling newly synthesized DNA during replication
Cell proliferating assay studies
Cell cycle analysis

For information on Baseclick kits containing all the reagents for the assays see: Baseclick kits

For a listing of the Baseclick kits see: Baseclick kits

pictograms

GHS08

signalword

Danger

hcodes

H340,H361

pcodes

P201 - P202 - P280 - P308 + P313 - P405 - P501

Hazard Classifications

Muta. 1B - Repr. 2

Storage Class

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

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Synthesis, susceptibility to enzymatic phosphorylation, cytotoxicity and in vitro antiviral activity of lipophilic pyrimidine nucleoside/carborane conjugates.

Bialek-Pietras M, et al.

Journal of Organometallic Chemistry, 865, 166-172 (2018)

Click chemistry as a reliable method for the high-density postsynthetic functionalization of alkyne-modified DNA.

Gierlich J, et al.

Organic Letters, 8(17), 3639-3642 (2006)

Site-directed spin-labeling of nucleic acids by click chemistry: detection of abasic sites in duplex DNA by EPR spectroscopy.

Jakobsen A, et al.

Journal of the American Chemical Society, 132(30), 10424-10428 (2010)

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Global Trade Item Number

SKU	GTIN
900584-500MG	04061833250372
900584-50MG	04061833250389