910074
27,27-Dimethyl-25-oxo-3,6,9,12,15,18,26-heptaoxaoctacosanoic acid
≥95%
Synonym(s):
2-2-2-2-2-2-6 PROTAC® linker, Bifunctional linker, OtBu-PEG6-acid
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About This Item
Empirical Formula (Hill Notation):
C23H44O10
Molecular Weight:
480.59
UNSPSC Code:
12352106
Assay:
≥95%
Form:
liquid
assay
≥95%
form
liquid
reaction suitability
reagent type: linker
functional group
carboxylic acid, ester
storage temp.
2-8°C
SMILES string
O=C(CCCCCCOCCOCCOCCOCCOCCOCC(O)=O)OC(C)(C)C
Application
This heterobifunctional, PEGylated crosslinker 27,27-dimethyl-25-oxo-3,6,9,12,15,18,26-heptaoxaoctacosanoic acid features a carboxyl group at one end and a t-butyl protected carboxylic acid at the other and exhibits both hydrophobic and hydrophilic moieties for use in biological applications. The linker can be used for bioconjugation or as a building block for synthesis of small molecules, conjugates of small molecules and/or biomolecules, or other tool compounds for chemical biology and medicinal chemistry that require ligation. Examples of applications include its synthetic incorporation into antibody-drug conjugates or pproteolysis-targeting chimeras (PROTAC® molecules) for targeted protein degradation where the linker region is referred to as 2-2-2-2-2-2-6.
Other Notes
Legal Information
PROTAC is a registered trademark of Arvinas Operations, Inc., and is used under license
Storage Class
10 - Combustible liquids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
Regulatory Information
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Ashton C Lai et al.
Angewandte Chemie (International ed. in English), 55(2), 807-810 (2015-11-26)
Proteolysis Targeting Chimera (PROTAC) technology is a rapidly emerging alternative therapeutic strategy with the potential to address many of the challenges currently faced in modern drug development programs. PROTAC technology employs small molecules that recruit target proteins for ubiquitination and