927465
BMK-alkyne
Synonym(s):
1-Bromohept-6-yn-2-one
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About This Item
Empirical Formula (Hill Notation):
C7H9BrO
Molecular Weight:
189.05
UNSPSC Code:
12352101
NACRES:
NA.22
MDL number:
form
liquid
Quality Level
refractive index
n/D 1.494
density
1.368
storage temp.
−20°C
SMILES string
BrCC(=O)CCCC#C
InChI
1S/C7H9BrO/c1-2-3-4-5-7(9)6-8/h1H,3-6H2
InChI key
SLVASQVSQAKKMN-UHFFFAOYSA-N
Application
BMK-alkyne is a probe that can be used for labeling cysteines through alkylation. A method was developed using cysteine-reactive compounds including this one to allow for unbiased analysis of proteomic data in quantitave applications (Zanon et al. 2021). The method uses light or heavy labeling with the isotopically labelled desthiobiotin azide (isoDTB) tag for mass spectrometry analysis (Zanon et al. 2020). Analysis then uses the isotopic tandem orthogonal proteolysis activity-based protein profiling (isoTOP-ABPP) workflow (Weerapana et al. 2010, Backus et al. 2016).
wgk
WGK 3
Storage Class
10 - Combustible liquids
flash_point_f
Not applicable
flash_point_c
Not applicable
Regulatory Information
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Isotopically Labeled Desthiobiotin Azide (isoDTB) Tags Enable Global Profiling of the Bacterial Cysteinome
Zanon, et al
Angewandte Chemie (International Edition in English), 2829-2836 (2020)
Global Trade Item Number
| SKU | GTIN |
|---|---|
| 927465-50MG | 04065268021866 |