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Merck
CN

927562

MSOD-alkyne

≥95%

Synonym(s):

2-(Methylsulfonyl)-5-(4-(prop-2-yn-1-yloxy)phenyl)-1,3,4-oxadiazole

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About This Item

Empirical Formula (Hill Notation):
C12H10N2O4S
CAS Number:
Molecular Weight:
278.28
MDL number:
NACRES:
NA.22
UNSPSC Code:
12352101
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Quality Level

assay

≥95%

form

powder

storage temp.

−20°C

Application

MSOD-alkyne is a probe that can be used to label cysteines through nucleophilic aromatic substitution. A method was developed using cysteine-reactive compounds including this one to allow for unbiased analysis of proteomic data in quantitative applications . The method uses light or heavy labeling with the isotopically labelled desthiobiotin azide (isoDTB) tag for mass spectrometry analysis . Analysis then uses the isotopic tandem orthogonal proteolysis activity-based protein profiling (isoTOP-ABPP) workflow .


Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

Regulatory Information

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Profiling the proteome-wide selectivity of diverse electrophiles
Zanon, et al
ChemRxiv : the preprint server for chemistry (2021)
Isotopically Labeled Desthiobiotin Azide (isoDTB) Tags Enable Global Profiling of the Bacterial Cysteinome
Zanon, et al
Angewandte Chemie (International Edition in English), 2829-2836 (2020)



Global Trade Item Number

SKUGTIN
927562-50MG04065268057360